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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.

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  • Select the specific GRN number below to view additional details about any GRAS Notice.
  • To sort by a specific field, click on the column header for that field.
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Records Found: 12 Page 1 of 1
(sorted Z-A)
Substance Date of closure FDA's Letter
682 Lecithin from canola Jul 7, 2017 FDA has no questions (in PDF) (151 kB)
637 Phosphatidylserine derived from soy lecithin Aug 4, 2016 At the notifier's request, FDA ceased to evaluate this notice
636 Phosphatidylserine derived from sunflower lecithin Jul 1, 2016 At the notifier's request, FDA ceased to evaluate this notice
534 Hydrogenated lecithin from soy Dec 22, 2014 FDA has no questions
533 Lecithin from canola Mar 20, 2015 FDA has no questions
226 Lecithin derived from krill Jan 3, 2008 FDA has no questions
212 Phospholipase A2 enzyme preparation from Streptomyces violaceruber expressing a gene encoding phospholipase A2 from the same species Mar 22, 2007 FDA has no questions
186 Soy lecithin enzymatically modified to have increased phosphatidylserine Jul 20, 2006 FDA has no questions
134 Soy protein hydrolyzate with enzyme-modified lecithin Jan 8, 2004 FDA has no questions
113 Lipase enzyme preparation from Aspergillus oryzae Jan 27, 2003 FDA has no questions
111 Lipase enzyme preparation from Aspergillus niger Dec 20, 2002 FDA has no questions
75 Lipase derived from Aspergillus oryzae carrying a gene encoding lipase from Fusarium oxysporum Aug 14, 2001 FDA has no questions

(sorted Z-A)
Substance Date of closure FDA's Letter