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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


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  • Select the specific GRN number below to view additional details about any GRAS Notice.
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Records Found: 734 Show All Page 1 of 15
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter
734 Ergothionine Pending
733 Purified steviol glycosides Pending
732 Docosahexaenoic acid oil produced in Schizochytrium sp. Pending
731 Docosahexaenoic acid oil produced in Schizochytrium sp. Pending
730 Arachidonic acid oil produced in Mortierella alpina Pending
729 Galacto-oligosaccharides Pending
728 Phospholipase C from Pseudomonas sp. 62186 produced in Bacillus licheniformis Pending
727 Trehalase from Trichoderma reesei produced in Trichoderma reesei Pending
726 Polyphenol extract from olive Pending
725 Inactivated Bacillus coagulans GBI-30, 6086 Pending
724 Preparation containing six bacterial phages specific to shiga-toxin producing Escherichia coli Pending
723 Benzalkonium chloride Pending
722 Lactobacillus plantarum Lp-115 Pending
721 Galacto-oligosaccharides Pending
720 Rice bran wax Pending
719 Orange pomace Pending
718 Calcium acid pyrophosphate Pending
717 Short-chain fructo-oligosaccharides Pending
716 Bovine milk osteopontin Pending
715 Rebaudioside D Pending
714 Subtilisin from Bacillus amyloliquefaciens produced in Bacillus subtilis Pending
713 Hydrolyzed pork cartilage Pending
712 Calcium acetate Pending
711 Glucan Pending
710 Basic methacrylate copolymer Pending
709 Pyrroloquinoline quinone disodium salt Pending
708 Triacylglycerol lipase from Rhizopus oryzae produced in Aspergillus niger Pending
707 Glucose oxidase from Penicillium produced in Trichoderma reesei Pending
706 Siraitia grosvenorii Swingle (Luo Han Guo) fruit extract Aug 17, 2017 FDA has no questions (in PDF) (93 kB)
705 Distarch phosphate Pending
704 Corn oil (by-product of ethanol production) Pending
703 Alpha-glucosidase from Aspergillus niger produced by Trichoderma reesi Pending
702 Purified steviol glycosides Sep 28, 2017 FDA has no questions (in PDF) (65 kB)
701 Pyrroloquinoline quinone disodium salt Sep 8, 2017 FDA has no questions (in PDF) (68 kB)
700 Paracoccus carotinifaciens extract containing carotenoids Pending
699 Trehalase from Myceliophthora sepedonium produced by Aspergillus niger Pending
698 Paramylon isolate from Euglena gracilis Jul 19, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (105 kB)
697 Dried biomass of Euglena gracilis Jul 19, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (105 kB)
696 Dolomite Pending
695 Dimethyl ether Aug 29, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (46 kB)
694 Pyrroloquinoline quinone disodium salt (PQQ) Sep 28, 2017 FDA has no questions (in PDF) (72 kB)
693 D-psicose Aug 28, 2017 FDA has no questions (in PDF) (97 kB)
692 Quinoa sprout extract Pending
691 Bacillus coagulans SANK 70258 spore preparation Pending
690 Fruit and vegetable vitamin extract At the notifier's request, FDA ceased to evaluate this notice (117 kB)
689 Phospholipase C from Bacillus thuringiensis produced in Bacillus licheniformis Pending
688 Sodium thiocyanate Pending
687 Inulin from Agave tequilana May 8, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (54 kB)
686 Curcumin from turmeric (Curcuma longa L.) Jul 11, 2017 FDA has no questions (in PDF) (152 kB)
685 Lactobacillus plantarum strain 299v Pending

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GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter
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