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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


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  • Select the specific GRN number below to view additional details about any GRAS Notice.
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Records Found: 709 Show All Page 1 of 15
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter
709 Pyrroloquinoline quinone disodium salt Pending
708 Triacylglycerol lipase from Rhizopus oryzae produced in Aspergillus niger Pending
707 Glucose oxidase from Penicillium produced in Trichoderma reesei Pending
706 Siraitia grosvenorii Swingle (Luo Han Guo) fruit extract Pending
705 Distarch phosphate Pending
704 Corn oil (by-product of ethanol production) Pending
703 Alpha-glucosidase from Aspergillus niger produced by Trichoderma reesi Pending
702 Purified steviol glycosides Pending
701 Pyrroloquinoline quinone disodium salt Pending
700 Paracoccus carotinifaciens extract containing carotenoids Pending
699 Trehalase from Myceliophthora sepedonium produced by Aspergillus niger Pending
698 Paramylon isolate from Euglena gracilis Pending
697 Dried biomass of Euglena gracilis Pending
696 Dolomite Pending
695 Dimethyl ether Pending
694 Pyrroloquinoline quinone disodium salt (PQQ) Pending
693 D-psicose Pending
692 Quinoa sprout extract Pending
691 Bacillus coagulans SANK 70258 spore preparation Pending
690 Fruit and vegetable vitamin extract Pending
689 Phospholipase C from Bacillus thuringiensis produced in Bacillus licheniformis Pending
688 Sodium thiocyanate Pending
687 Inulin from Agave tequilana May 8, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (54 kB)
686 Curcumin from turmeric (Curcuma longa L.) Pending
685 Lactobacillus plantarum strain 299v Pending
684 Mung bean protein isolate Pending
683 Canola protein isolate May 10, 2017 FDA has no questions (in PDF) (75 kB)
682 Lecithin from canola Pending
681 Isomaltulose Pending
680 Alpha-L-arabinofuranosidase from Talaromyces pinophilus produced by Trichoderma reesei May 24, 2017 FDA has no questions (in PDF) (101 kB)
679 Dealcoholized fermented orange juice May 10, 2017 FDA has no questions (in PDF) (67 kB)
678 Alpha-cyclodextrin Apr 14, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (49 kB)
677 Docosahexaenoic acid oil produced in Schizochytrium sp. May 2, 2017 FDA has no questions (in PDF) (101 kB)
676 Colicin May 15, 2017 FDA has no questions (in PDF) (90 kB)
675 Xylanase enzyme preparation produced by Trichoderma reesei carrying a xylanase gene from Talaromyces leycettanus Pending
674 Isomalto-oligosaccharides Pending
673 Algal fat derived from Prototheca moriformis (S7737) Mar 27, 2017 FDA has no questions (in PDF) (76 kB)
672 Preparation containing five bacterial monophages specific to Shigella spp. Mar 27, 2017 FDA has no questions (in PDF) (109 kB)
671 Galacto-oligosaccharides (GOS) Apr 11, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (62 kB)
670 Inactivated Bacillus coagulans GBI-30, 6086 Mar 15, 2017 FDA has no questions (in PDF) (47 kB)
669 Cow’s milk-derived lactoferrin Mar 9, 2017 FDA has no questions (in PDF) (168 kB)
668 Sodium formate Mar 9, 2017 FDA has no questions (in PDF) (106 kB)
667 Rebaudioside M Feb 17, 2017 FDA has no questions (in PDF) (115 kB)
666 Chondroitin sodium sulfate Mar 15, 2017 FDA has no questions (in PDF) (109 kB)
665 Lactoperoxidase system Dec 14, 2016 At the notifier's request, FDA ceased to evaluate this notice
664 Alpha-amylase from Cytophaga sp. expressed in Bacillus licheniformis Jan 31, 2017 FDA has no questions (in PDF) (79 kB)
663 Distarch phosphate Sep 30, 2016 At the notifier's request, FDA ceased to evaluate this notice
662 Glucosylated steviol glycosides (minimum purity 95%) Sep 29, 2016 FDA has no questions
661 Fucus vesiculosus concentrate Feb 10, 2017 FDA has no questions (in PDF) (85 kB)
660 Bacillus coagulans GBI-30, 6086 Jan 13, 2017 FDA has no questions (in PDF) (81 kB)

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GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter
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