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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


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  • Select the specific GRN number below to view additional details about any GRAS Notice.
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Records Found: 908 Show All Page 1 of 19
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter
908 Lipase from Penicillium camemberti Pending
907 Wheat seed oil Pending
906 Wheat polar lipids Pending
905 Bacillus subtilis SG188 Pending
904 Fusarium novum. yellowstonensis mycelium Pending
903 Quillaia extract type 2 Pending
902 Neohesperidin dihydrochalcone Pending
901 Glucosyl hesperidin Pending
900 Corn oil Pending
899 Citric acid esters of mono- and diglycerides Pending
898 Dried milk fat Pending
897 2’-O-fucosyllactose Pending
896 Alpha-galacto-oligosaccharides Pending
895 Lacto-N-neotetraose Pending
894 White mulberry leaf extract Pending
893 D-psicose Pending
892 Refined shea butter Pending
891 Cellulase produced by Trichoderma reesei Pending
890 Corn oil derived from distillers grains Pending
889 Wheat germ extract Pending
888 Preparation containing three bacterial phages specific to Salmonella Feb 28, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (36 KB)
887 Menaquinone-7 Pending
886 Monoacylglycerides from grape seed Pending
885 Vinyl acetate-vinyl laurate copolymer Pending
884 Rice bran extract Pending
883 Ilex guayusa leaf aqueous extract Apr 28, 2020 FDA has no questions (in PDF) (46 KB)
882 Rebaudioside M Pending
881 6’-sialyllactose sodium salt Pending
880 3’-sialyllactose sodium salt Pending
879 Fava bean protein isolate Mar 23, 2020 FDA has no questions (502 KB)
878 Glucosylated steviol glycosides Pending
877 Bifidobacterium longum BB536 Dec 26, 2019 FDA has no questions (in PDF) (75 KB)
876 Hydroxytyrosol Jan 21, 2020 FDA has no questions (in PDF) (88 KB)
875 Bifidobacterium animalis subsp. lactis AD011 Pending
874 Corn protein Apr 29, 2020 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (44 KB)
873 Cranberry extract Pending
872 Bifidobacterium animalis subsp. lactis UABla-12 Dec 9, 2019 FDA has no questions (in PDF) (62 KB)
871 Lactobacillus acidophilus DDS-1 Oct 23, 2019 FDA has no questions (in PDF) (49 KB)
870 Ilex guayusa leaf hydroethanolic extract Mar 20, 2020 FDA has no questions (in PDF) (550 MB)
869 Ilex guayusa leaf aqueous extract Mar 20, 2020 FDA has no questions (in PDF) (550 KB)
868 Coffee fruit extract Pending
867 Rebaudioside M Sep 3, 2019 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (36 KB)
866 Lipase from Penicillium camemberti Pending
865 Lactobacillus acidophilus NCFM Pending
864 Bacillus coagulans SNZ 1969 spore preparation Pending
863 Β-lactoglobulin produced by Trichoderma reesei Mar 25, 2020 FDA has no questions (in PDF) (637 KB)
862 Algal oil (40% docosahexaenoic acid) from Schizochytrium sp. strain ONC-T18 Pending
861 Pullulanase from Bacillus deramificans produced in Bacillus subtilis Pending
860 Algal oil (36% docosahexaenoic acid) from Schizochytrium sp. strain DHF Sep 3, 2019 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (59 KB)
859 2'-fucosyllactose Sep 6, 2019 At the notifier's request, FDA ceased to evaluate this notice (in PDF))

Show All 

jump to page of 19 


GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter

679661  

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