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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


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  • Select the specific GRN number below to view additional details about any GRAS Notice.
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Records Found: 29 Page 1 of 1
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter
871 Lactobacillus acidophilus DDS-1 Oct 23, 2019 FDA has no questions (in PDF) (49 KB)
865 Lactobacillus acidophilus NCFM Pending
847 Lactobacillus plantarum ECGC 13110402 Sep 30, 2019 FDA has no questions (in PDF) (86 KB)
845 Lactobacillus rhamnosus LGG Pending
840 Lactobacillus paracasei strain F19 Aug 27, 2019 FDA has no questions (in PDF) (76 KB)
820 Lactobacillus fermentum CECT5716 Apr 3, 2019 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (35.2 kB)
810 Lactobacillus paracasei subsp. paracasei strain F-19e Apr 5, 2019 FDA has no questions (in PDF) (178 kB)
760 Lactobacillus curvatus DSM 18775 Jan 29, 2019 FDA has no questions (in PDF) (77 KB)
758 Lactobacillus helveticus R0052, Bifidobacterium longum subsp. infantis R0033, and Bifidobacterium bifidum R0071 Aug 20, 2018 FDA has no questions (in PDF) (103 kB)
736 Lactobacillus casei subsp. paracasei Lpc-37 Apr 11, 2018 FDA has no questions (in PDF) (73 kB)
722 Lactobacillus plantarum Lp-115 Feb 16, 2018 FDA has no questions (in PDF) (67 kB)
685 Lactobacillus plantarum strain 299v Oct 31, 2017 FDA has no questions (in PDF) (44 kB)
668 Sodium formate Mar 9, 2017 FDA has no questions (in PDF) (106 kB)
531 Lactobacillus fermentum CECT5716 Mar 20, 2015 FDA has no questions
502 Lactobacillus acidophilus La-14 Aug 19, 2014 FDA has no questions
463 Lactobacillus acidophilus strain NP 28, Lactobacillus acidophilus strain NP51, Lactobacillus subsp. lactis strain NP7, and Pediococcus acidilactici strain NP3 Jan 16, 2014 At notifier's request, FDA ceased to evaluate the notice
440 Lactobacillus reuteri strain NCIMB 30242 Feb 12, 2013 FDA has no questions
429 Lactobacillus casei strain Shirota Dec 10, 2012 FDA has no questions
410 Lactobacillus reuteri strain DSM 17938 Mar 26, 2012 FDA has no questions
409 Lactobacillus reuteri strain NCIMB 30242 Jan 10, 2012 At notifier's request, FDA ceased to evaluate the notice
378 Cultured [dairy sources, sugars, wheat, malt, and fruit- and vegetable-based sources] fermented by [Streptococcus thermophilus, Bacillus coagulans, Lactobacillus acidophilus, Lactobacillus paracasei subsp. paracasei, Lactobacillus plantarum, Lactobacillus sakei, Lactobacillus bulgaricus and Proprionibacterium freudenreichii subsp. shermanii or mixtures of these strains] Mar 26, 2012 FDA has no questions
357 Lactobacillus acidophilus NCFM Apr 19, 2011 FDA has no questions
324 Heat-killed Lactobacillus plantarum Jul 7, 2010 At notifier's request, FDA ceased to evaluate the notice
288 Lactobacillus rhamnosus strain HN001 Nov 1, 2009 FDA has no questions
281 Lactobacillus rhamnosus strain HN001 produced in a milk-based medium Aug 31, 2009 FDA has no questions
254 Lactobacillus reuteri strain DSM 17938 Nov 18, 2008 FDA has no questions
240 Corn, cane, or beet sugar cultured with Lactobacillus paracasei subsp. paracasei, Bacillus coagulans LA-1, or Propionibacterium freudenreichii subsp. shermanii, or mixtures of these microorganisms Oct 24, 2008 FDA has no questions
231 Lactobacillus casei subsp. rhamnosus strain GG May 29, 2008 FDA has no questions
171 Lactobacillus acidophilus, Lactobacillus lactis, and Pediococcus acidilactici Dec 7, 2005 FDA has no questions (additional correspondence available)

GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter

679662  

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