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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


Search and display hints:

  • Select the specific GRN number below to view additional details about any GRAS Notice.
  • To sort by a specific field, click on the column header for that field.
  • To browse the records, use the Show All, First/Previous/Next/Last, and Jump To options at the bottom of the data table.
  • To search for a specific substance/term, enter the term in the Search box and select Show Items to display only those records that contain the selected term. (The search results also includes terms not shown on this page, but included in the full record on the detail page.)
  • The search results will return hits of records containing words that include the search term. For example, a search for the color red will return results that include terms such as reduce, ingredient, and cultured. To limit results to only the searched term, place a space before and after the word in the basic search or in the advanced search “this exact phrase” field.
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Records Found: 7 Page 1 of 1
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter
789 Erythritol Feb 20, 2019 FDA has no questions (in PDF) (79 kB)
401 Erythritol Mar 22, 2012 FDA has no questions
382 Erythritol Nov 21, 2011 FDA has no questions
297 Erythritol fatty acid esters Dec 15, 2009 FDA has no questions
208 Erythritol Jan 25, 2007 FDA has no questions
203 Erythritol fatty acid esters Nov 15, 2006 At notifier's request, FDA ceased to evaluate the notice
76 Erythritol Sep 11, 2001 FDA has no questions

GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter

679662  

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