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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


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  • Select the specific GRN number below to view additional details about any GRAS Notice.
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Records Found: 13 Page 1 of 1
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter
669 Cow’s milk-derived lactoferrin Mar 9, 2017 FDA has no questions (in PDF) (168 kB)
612 Fractionated whey protein isolate containing cow’s milk derived lactoferrin, lactoperoxidase, and transforming growth factor β2 May 19, 2016 At the notifier's request, FDA ceased to evaluate this notice
611 Fractionated whey protein isolate containing cow’s milk derived lactoferrin, lactoperoxidase, and transforming growth factor β2 Apr 15, 2016 At notifier's request, FDA ceased to evaluate the notice
465 Cow's milk-derived lactoferrin Feb 18, 2014 FDA has no questions
464 Cow's milk-derived lactoferrin Feb 18, 2014 FDA has no questions
423 Cow's milk-derived lactoferrin May 2, 2012 At notifier's request, FDA ceased to evaluate the notice
235 Human lactoferrin purified from rice Mar 12, 2010 At notifier's request, FDA ceased to evaluate the notice
189 Lactoferrin (human) purified from bovine milk Dec 10, 2009 At notifier's request, FDA ceased to evaluate the notice
162 Lactoferrin (human) purified from rice Nov 16, 2006 At notifier's request, FDA ceased to evaluate the notice.
130 Bovine milk-derived lactoferrin Aug 21, 2003 FDA has no questions (additional correspondence available)
77 Milk-derived lactoferrin Aug 14, 2001 FDA has no questions
67 Milk-derived lactoferrin Oct 23, 2001 FDA has no questions
42 Milk-derived lactoferrin Mar 26, 2001 Notice does not provide a basis for a GRAS determination (additional correspondence available)

GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter

679661  

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