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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


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  • Select the specific GRN number below to view additional details about any GRAS Notice.
  • To sort by a specific field, click on the column header for that field.
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  • To search for a specific substance/term, enter the term in the Search box and select Show Items to display only those records that contain the selected term. (The search results also includes terms not shown on this page, but included in the full record on the detail page.)
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Records Found: 8 Page 1 of 1
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter
784 Siraitia grosvenorii Swingle (Luo Han Guo) fruit extract Nov 20, 2018 FDA has no questions (in PDF) (664 kB)
706 Siraitia grosvenorii Swingle (Luo Han Guo) fruit extract Aug 17, 2017 FDA has no questions (in PDF) (93 kB)
629 Siraitia grosvenorii Swingle (Luo Han Guo) fruit extract Jul 15, 2016 At the notifier's request, FDA ceased to evaluate this notice
627 Siraitia grosvenorii Swingle (Luo Han Guo) fruit juice concentrate Oct 11, 2016 FDA has no questions
556 Siraitia grosvenorii Swingle (Luo Han Guo) fruit extract Jun 17, 2015 FDA has no questions
522 Siraitia grosvenorii Swingle (Luo Han Guo) fruit extract Dec 8, 2014 FDA has no questions
359 Siraitia grosvenorii Swingle (Luo Han Guo) fruit extracts (SGFE) Apr 11, 2011 FDA has no questions
301 Siraitia grosvenorii Swingle (Luo Han Guo) fruit extract (SGFE) Jan 15, 2010 FDA has no questions (additional correspondence available)

GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter

679661  

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