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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


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  • Select the specific GRN number below to view additional details about any GRAS Notice.
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Records Found: 38 Page 1 of 1
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter
795 Purified steviol glycosides Sep 25, 2018 FDA has no questions (in PDF) (105 kB)
768 Stevia leaf extract Aug 13, 2018 FDA has no questions (in PDF) (100 kB)
702 Purified steviol glycosides Sep 28, 2017 FDA has no questions (in PDF) (65 kB)
555 High purity steviol glycosides (minimum purity 95%) consisting primarily of rebaudioside A. Apr 21, 2015 FDA has no questions
548 High purity rebaudioside D Apr 22, 2015 FDA has no questions
536 High purity rebaudioside C Feb 12, 2015 FDA has no questions
516 Steviol glycosides with rebaudioside A and stevioside as the principal components Oct 31, 2014 FDA has no questions
512 High purity Rebaudioside M Oct 24, 2014 FDA has no questions
493 High purity steviol glycosides (minimum purity 95%) May 30, 2014 FDA has no questions
473 Purified steviol glycosides with rebaudioside X as the principal component Dec 17, 2013 FDA has no questions
467 Rebaudioside A purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni Nov 25, 2013 FDA has no questions
461 Rebaudioside A purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni (rebaudioside A) Aug 14, 2013 FDA has no questions
456 Rebaudioside D purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni (rebaudioside D) Jul 1, 2013 FDA has no questions
452 Enzyme-modified steviol glycosides Jul 1, 2013 FDA has no questions
448 Enzyme-modified steviol glycosides May 3, 2013 FDA has no questions
418 Rebaudioside A purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni (rebaudioside A) Jun 7, 2012 FDA has no questions
395 Steviol glycosides with rebaudioside A and stevioside as the principal components Jan 24, 2012 FDA has no questions
393 Rebaudioside A purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni (rebaudioside A) Jan 23, 2012 FDA has no questions
389 Steviol glycosides with stevioside as the principal component Jan 18, 2012 FDA has no questions
388 Rebaudioside A purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni (rebaudioside A) Jan 9, 2012 FDA has no questions
380 Rebaudioside A purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni (rebaudioside A) Nov 28, 2011 FDA has no questions
375 Enzyme-modified steviol glycosides Sep 2, 2011 FDA has no questions
369 Rebaudioside A purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni   Oct 11, 2011 FDA has no questions
367 Purified steviol glycosides with rebaudioside A and stevioside as the principal components Jul 8, 2011 FDA has no questions
365 Rebaudioside A purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni (rebaudioside A)   Aug 18, 2011 FDA has no questions
354 Rebaudioside A purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni (rebaudioside A) Jul 15, 2011 FDA has no questions
349 Purified steviol glycosides with rebaudioside A and stevioside as the principal components Jul 14, 2011 FDA has no questions
348 Stevioside purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni (stevioside) Jul 14, 2011 FDA has no questions
337 Enzyme-modified steviol glycosides preparation (EMSGP) Jun 17, 2011 FDA has no questions
329 Rebaudioside A purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni Sep 10, 2010 FDA has no questions
318 Rebaudioside A purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni May 15, 2010 FDA has no questions
303 Rebaudioside A purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni Mar 22, 2010 FDA has no questions
287 Purified steviol glycosides with rebaudioside A and stevioside as the principal components Aug 28, 2009 FDA has no questions
282 Rebaudioside A purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni Aug 11, 2009 FDA has no questions
278 Rebaudioside A purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni Jul 20, 2009 FDA has no questions
275 Purified steviol glycosides with rebaudioside A as the principal component Jun 11, 2009 FDA has no questions
253 Rebaudioside A purified from Stevia rebaudiana (Bertoni) Bertoni Dec 17, 2008 FDA has no questions
252 Rebaudioside A purified from Stevia rebaudiana (Bertoni) Bertoni Dec 17, 2008 FDA has no questions

GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter

679663  

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