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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


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  • Select the specific GRN number below to view additional details about any GRAS Notice.
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Records Found: 873 Show All Page 1 of 18
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter
873 Cranberry extract Pending
872 Bifidobacterium animalis subsp. lactis UABla-12 Pending
871 Lactobacillus acidophilus DDS-1 Pending
870 Ilex guayusa leaf hydroethanolic extract Pending
869 Ilex guayusa leaf extract Pending
868 Coffee fruit extract Pending
867 Rebaudioside M Sep 3, 2019 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (36 KB)
866 Lipase from Penicillium camemberti Pending
865 Lactobacillus acidophilus NCFM Pending
864 Bacillus coagulans SNZ 1969 spore preparation Pending
863 Β-lactoglobulin produced by Trichoderma reesei Pending
862 Algal oil (40% docosahexaenoic acid) from Schizochytrium sp. strain ONC-T18 Pending
861 Pullulanase from Bacillus deramificans produced in Bacillus subtilis Pending
860 Algal oil (36% docosahexaenoic acid) from Schizochytrium sp. strain DHF Sep 3, 2019 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (59 KB)
859 2'-fucosyllactose Sep 6, 2019 At the notifier's request, FDA ceased to evaluate this notice (in PDF))
858 Glucosylated steviol glycosides Oct 4, 2019 FDA has no questions (in PDF) (86 KB)
857 Phospholipase A1 produced by Aspergillus niger Pending
856 Bifidobacterium animalis subsp. lactis strain BB-12 Pending
855 Bifidobacterium animalis subsp. lactis strain R0421 Pending
854 Inulin from Agave tequilana Pending
853 Lysozyme produced by Trichoderma reesei Pending
852 2’-fucosyllactose Pending
851 Pea protein Pending
850 Shea olein Pending
849 Inulin from artichoke Oct 30, 2019 FDA has no questions (in PDF) (129 KB)
848 Pea and rice protein fermented by Shitake mycelia Pending
847 Lactobacillus plantarum ECGC 13110402 Sep 30, 2019 FDA has no questions (in PDF) (86 KB)
846 Rebaudioside M Aug 23, 2019 FDA has no questions (in PDF) (102 KB)
845 Lactobacillus rhamnosus LGG Pending
844 Algal oil (55% docosahexaenoic acid) from Schizochytrium sp. strain FCC-3204 Oct 18, 2019 FDA has no questions (in PDF) (105 KB)
843 Algal oil (35% docosahexaenoic acid) from Schizochytrium sp. strain FCC-1324 Oct 18, 2019 FDA has no questions (in PDF) (85 KB)
842 Maltogenic alpha-amylase Pending
841 Saccharomyces cerevisiae expressing L-lactate dehydrogenase from Rhizopus oryzae Pending
840 Lactobacillus paracasei strain F19 Aug 27, 2019 FDA has no questions (in PDF) (76 KB)
839 Purified steviol glycosides Jul 8, 2019 FDA has no questions (in PDF) (77 KB)
838 Purified steviol glycosides Jul 12, 2019 FDA has no questions (in PDF) (83 KB)
837 Hydroxytyrosol Jun 5, 2019 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (54 kB)
836 Algal oil (50-60% docosahexaenoic acid) from Schizochytrium sp. HS01 Sep 3, 2019 FDA has no questions (in PDF) (74 KB)
835 Ilex guayusa leaf extract May 22, 2019 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (35 kB)
834 Preparation containing bacterial phages specific to shiga-toxin producing Escherichia coli Pending
833 Lacto-N-tetraose Oct 7, 2019 FDA has no questions (in PDF) (105 KB)
832 Acid prolyl endopeptidase produced by Aspergillus niger Pending
831 Bacillus subtilis DE111 Oct 7, 2019 FDA has no questions (in PDF) (73 KB)
830 Chicory flour May 22, 2019 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (54 kB)
829 Dried biomass of Aspergillus oryzae fermented with minerals Pending
828 D-psicose Pending
827 Preparation containing three bacterial phages specific to several Escherichia coli serotypes Aug 12, 2019 FDA has no questions (in PDF) (76 KB)
826 Dihydroquercetin Sep 25, 2019 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (35 KB)
825 Beta-galactosidase from Kluyveromyces lactis Pending
824 Bacteriocin preparations specific to Salmonella Pending

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jump to page of 18 


GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter

679661  

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