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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


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  • Select the specific GRN number below to view additional details about any GRAS Notice.
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Records Found: 819 Show All Page 1 of 17
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter
819 Fatty acid ethyl esters from Alaskan pollack Pending
818 Isomalto-oligosaccharides Pending
817 Serine endopeptidase from Malbranchea cinnamomea produced in Trichoderma reesei Pending
816 Xylooligosaccharides from sugarcane Pending
815 2'-fucosyllactose and difucosyllactose Pending
814 Bifidobacterium bifidum BGN4 Pending
813 Bifidobacterium longum BORI Pending
812 Rebaudioside M Pending
811 Phospholipase A1 produced by Aspergillus oryzae Pending
810 Lactobacillus paracasei subsp. paracasei strain F-19e Pending
809 Alpha-lactalbumin Pending
808 Lipase from Aspergillus tubingensis produced in Trichoderma reesei Pending
807 Streptococcus salivarius M18 Pending
806 Dolomite Pending
805 Apple peel powder Pending
804 Pea protein Pending
803 Pea protein Pending
802 Endolysin Pending
801 Chymosin enzyme from Camelius dromedarius produced in Aspergillus niger Pending
800 gamma-oryzanol Pending
799 Rebaudioside M Sep 25, 2018 FDA has no questions (in PDF) (112 kB)
798 Saccharomyces cerevisiae strain yBBS002 Pending
797 Fructooligosaccharides Pending
796 Orange extract (85% hesperidin) Pending
795 Purified steviol glycosides Sep 25, 2018 FDA has no questions (in PDF) (105 kB)
794 Shiitake, pea, and rice protein fermented with Lentinula edodes Pending
793 Cultured corn starch fermented by Corynebacterium stationis Pending
792 Cultured corn starch fermented by Corynebacterium glutamicum Pending
791 Urolithin A Pending
790 Steviol glycosides (minimum purity 95%) Pending
789 Erythritol Pending
788 Pea protein Oct 12, 2018 FDA has no questions (in PDF) (249 kB)
787 Quinoa sprout powder Sep 9, 2018 FDA has no questions (in PDF) (94 kB)
786 Calcium propionate Pending
785 Calcium chloride Pending
784 Siraitia grosvenorii Swingle (Luo Han Guo) fruit extract Pending
783 Triacylglycerol lipase from Rhizopus oryzae produced in Aspergillus niger Pending
782 L-arabinose Aug 29, 2018 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (47 kB)
781 Alpha-tocopherol (fruit and vegetable derived) Pending
780 Rebaudioside M Jul 31, 2018 FDA has no questions (in PDF) (115 kB)
779 Isomalto-oligosaccharides Oct 19, 2018 FDA has no questions (in PDF) (92 kB)
778 Hemp seed oil Pending
777 Algal oil (55% docosahexaenoic acid) from Schizochytrium sp. FCC-3204 Oct 26, 2018 FDA has no questions (in PDF) (233 kB)
776 Algal oil (35% docosahexaenoic acid) from Schizochytrium sp. FCC-1324 Oct 26, 2018 FDA has no questions (in PDF) (573 kB)
775 Colicin Oct 26, 2018 FDA has no questions (in PDF) (80 kB)
774 Glutaminase from Bacillus licheniformis produced in Bacillus licheniformis Pending
773 Dried biomass of Chlamydomonas reinhardtii Pending
772 Palmitoylated green tea catechins Pending
771 Hemp seed protein Pending
770 Potassium polyaspartate Sep 11, 2018 FDA has no questions (in PDF) (789 kB)

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GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter

679663  

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