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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


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  • Select the specific GRN number below to view additional details about any GRAS Notice.
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Records Found: 755 Show All Page 1 of 16
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter
757 Preparation containing two bacterial phages specific to Escherichia coli O157 Pending
756 Endo-1,4-beta-glucanase from Trichoderma reesei Pending
755 D-psicose Pending
754 Algal oil (87% oleic acid) derived from Prototheca moriformis strain S6697 Pending
753 Sodium thiocyanate Pending
752 Preparation containing the bacterial monophages, BP-63 and LVR16-A, specific to Salmonella Pending
751 Maltogenic alpha-amylase from Bacillus stearothermophilus produced in Bacillus subtilis Pending
748 Tomato powder Pending
747 Calcium lactate Pending
746 Maltogenic amylase from Geobacillus stearothermophilus produced in Bacillus subtilis Pending
745 Steviol glycosides consisting primarily of rebaudioside M Pending
744 Steviol glycosides consisting primarily of rebaudioside M Pending
743 β-galactosidase from Papiliotrema terrestris Pending
742 Duckweed (subfamily Lemnoideae) powder Pending
741 Dimethyl ether Pending
740 Glycolipids from Dacryopinax spathularia Pending
739 Mannanase enzyme from Talaromyces leycettanus produced in Aspergillus niger Pending
738 Thaumatin Pending
737 Soy leghemoglobin Pending
736 Lactobacillus casei subsp. paracasei Lpc-37 Pending
735 2’-Fucosyllactose Pending
734 Ergothionine Pending
733 Purified steviol glycosides Jan 9, 2018 FDA has no questions (in PDF) (69 kB)
732 Docosahexaenoic acid oil produced in Schizochytrium sp. Pending
731 Docosahexaenoic acid oil produced in Schizochytrium sp. Pending
730 Arachidonic acid oil produced in Mortierella alpina Pending
729 Galacto-oligosaccharides Pending
728 Phospholipase C from Pseudomonas sp. 62186 produced in Bacillus licheniformis Nov 13, 2017 FDA has no questions (in PDF) (47 kB)
727 Trehalase from Trichoderma reesei produced in Trichoderma reesei Pending
726 Polyphenol extract from olive Pending
725 Inactivated Bacillus coagulans GBI-30, 6086 Pending
724 Preparation containing six bacterial phages specific to shiga-toxin producing Escherichia coli Pending
723 Benzalkonium chloride Dec 18, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (41 kB)
722 Lactobacillus plantarum Lp-115 Pending
721 Galacto-oligosaccharides Dec 19, 2017 FDA has no questions (in PDF) (69 kB)
720 Rice bran wax Jan 16, 2018 FDA has no questions (in PDF) (73 kB)
719 Orange pomace Dec 26, 2017 FDA has no questions (in PDF) (66 kB)
718 Calcium acid pyrophosphate Oct 17, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (32 kB)
717 Short-chain fructo-oligosaccharides Pending
716 Bovine milk osteopontin Pending
715 Rebaudioside D Oct 24, 2017 FDA has no questions (in PDF) (69 kB)
714 Subtilisin from Bacillus amyloliquefaciens produced in Bacillus subtilis Pending
713 Hydrolyzed pork cartilage Pending
712 Calcium acetate Pending
711 Glucan Dec 26, 2017 FDA has no questions (in PDF) (49 kB)
710 Basic methacrylate copolymer Dec 8, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (50 kB)
709 Pyrroloquinoline quinone disodium salt Pending
708 Triacylglycerol lipase from Rhizopus oryzae produced in Aspergillus niger Oct 10, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (52 kB)
707 Glucose oxidase from Penicillium produced in Trichoderma reesei Nov 24, 2017 FDA has no questions (in PDF) (51 kB)
706 Siraitia grosvenorii Swingle (Luo Han Guo) fruit extract Aug 17, 2017 FDA has no questions (in PDF) (93 kB)

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GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter

679661  

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