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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


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Records Found: 819 Show 50 records at a time
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter
819 Fatty acid ethyl esters from Alaskan pollack Pending
818 Isomalto-oligosaccharides Pending
817 Serine endopeptidase from Malbranchea cinnamomea produced in Trichoderma reesei Pending
816 Xylooligosaccharides from sugarcane Pending
815 2'-fucosyllactose and difucosyllactose Pending
814 Bifidobacterium bifidum BGN4 Pending
813 Bifidobacterium longum BORI Pending
812 Rebaudioside M Pending
811 Phospholipase A1 produced by Aspergillus oryzae Pending
810 Lactobacillus paracasei subsp. paracasei strain F-19e Pending
809 Alpha-lactalbumin Pending
808 Lipase from Aspergillus tubingensis produced in Trichoderma reesei Pending
807 Streptococcus salivarius M18 Pending
806 Dolomite Pending
805 Apple peel powder Pending
804 Pea protein Pending
803 Pea protein Pending
802 Endolysin Pending
801 Chymosin enzyme from Camelius dromedarius produced in Aspergillus niger Pending
800 gamma-oryzanol Pending
799 Rebaudioside M Sep 25, 2018 FDA has no questions (in PDF) (112 kB)
798 Saccharomyces cerevisiae strain yBBS002 Pending
797 Fructooligosaccharides Pending
796 Orange extract (85% hesperidin) Pending
795 Purified steviol glycosides Sep 25, 2018 FDA has no questions (in PDF) (105 kB)
794 Shiitake, pea, and rice protein fermented with Lentinula edodes Pending
793 Cultured corn starch fermented by Corynebacterium stationis Pending
792 Cultured corn starch fermented by Corynebacterium glutamicum Pending
791 Urolithin A Pending
790 Steviol glycosides (minimum purity 95%) Pending
789 Erythritol Pending
788 Pea protein Oct 12, 2018 FDA has no questions (in PDF) (249 kB)
787 Quinoa sprout powder Sep 9, 2018 FDA has no questions (in PDF) (94 kB)
786 Calcium propionate Pending
785 Calcium chloride Pending
784 Siraitia grosvenorii Swingle (Luo Han Guo) fruit extract Pending
783 Triacylglycerol lipase from Rhizopus oryzae produced in Aspergillus niger Pending
782 L-arabinose Aug 29, 2018 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (47 kB)
781 Alpha-tocopherol (fruit and vegetable derived) Pending
780 Rebaudioside M Jul 31, 2018 FDA has no questions (in PDF) (115 kB)
779 Isomalto-oligosaccharides Oct 19, 2018 FDA has no questions (in PDF) (92 kB)
778 Hemp seed oil Pending
777 Algal oil (55% docosahexaenoic acid) from Schizochytrium sp. FCC-3204 Oct 26, 2018 FDA has no questions (in PDF) (233 kB)
776 Algal oil (35% docosahexaenoic acid) from Schizochytrium sp. FCC-1324 Oct 26, 2018 FDA has no questions (in PDF) (573 kB)
775 Colicin Oct 26, 2018 FDA has no questions (in PDF) (80 kB)
774 Glutaminase from Bacillus licheniformis produced in Bacillus licheniformis Pending
773 Dried biomass of Chlamydomonas reinhardtii Pending
772 Palmitoylated green tea catechins Pending
771 Hemp seed protein Pending
770 Potassium polyaspartate Sep 11, 2018 FDA has no questions (in PDF) (789 kB)
769 Vitamin C (fruit and vegetable derived) Oct 23, 2018 FDA has no questions (in PDF) (72 kB)
768 Stevia leaf extract Aug 13, 2018 FDA has no questions (in PDF) (100 kB)
767 Polyvinyl alcohol Sep 19, 2018 FDA has no questions (in PDF) (57 kB)
766 3'-sialyllactose sodium salt Sep 26, 2018 FDA has no questions (in PDF) (81 kB)
765 Hulled hemp seed Pending
764 Rebaudioside D Jul 10, 2018 FDA has no questions (in PDF ) (111 kB)
763 Alpha-lactalbumin Pending
762 Carnobacterium divergens M35 preparation Aug 14, 2018 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (31 kB)
761 Esterified propoxylated glycerol May 25, 2018 FDA has no questions (in PDF) (105 kB)
760 Lactobacillus curvatus DSM 18775 Pending
759 Steviol glycosides consisting primarily of rebaudioside M produced in Yarrowia lipolytica May 25, 2018 FDA has no questions (in PDF) (106 kB)
758 Lactobacillus helveticus R0052, Bifidobacterium longum subsp. infantis R0033, and Bifidobacterium bifidum R0071 Aug 20, 2018 FDA has no questions (in PDF) (103 kB)
757 Preparation containing two bacterial phages specific to Escherichia coli O157 Aug 3, 2018 FDA has no questions (in PDF) (67 kB)
756 Endo-1,4-beta-glucanase from Trichoderma reesei Pending
755 D-psicose May 10, 2018 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (56 kB)
754 Algal oil (87% oleic acid) derived from Prototheca moriformis strain S6697 Jul 23, 2018 FDA has no questions (in PDF) (111 kB)
753 Sodium thiocyanate Jul 31, 2018 FDA has no questions (in PDF) (56 kB)
752 Preparation containing the bacterial monophages, BP-63 and LVR16-A, specific to Salmonella Jul 13, 2018 FDA has no questions (in PDF) (57 kB)
751 Maltogenic alpha-amylase from Bacillus stearothermophilus produced in Bacillus subtilis Pending
750 Beta-glucosidase from Aspergillus niger Pending
749 2’-O-fucosyllactose Apr 23, 2018 FDA has no questions (in PDF) (95 kB)
748 Tomato powder Apr 19, 2018 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (44 kB)
747 Calcium lactate Jun 1, 2018 FDA has no questions (in PDF) (76 kB)
746 Maltogenic amylase from Geobacillus stearothermophilus produced in Bacillus subtilis Jun 13, 2018 FDA has no questions (in PDF) (104 kB)
745 Steviol glycosides consisting primarily of rebaudioside M Apr 20, 2018 FDA has no questions (in PDF) (103 kB)
744 Steviol glycosides consisting primarily of rebaudioside M Mar 23, 2018 FDA has no questions (in PDF) (131 kB)
743 β-galactosidase from Papiliotrema terrestris Jun 1, 2018 FDA has no questions (in PDF) (68 kB)
742 Duckweed (subfamily Lemnoideae) powder Aug 22, 2018 FDA has no questions (in PDF) (64 kB)
741 Dimethyl ether May 18, 2018 FDA has no questions (in PDF) (72 kB)
740 Glycolipids from Dacryopinax spathularia May 17, 2018 FDA has no questions (in PDF) (93 kB)
739 Mannanase enzyme from Talaromyces leycettanus produced in Aspergillus niger Pending
738 Thaumatin Apr 18, 2018 FDA has no questions (in PDF) (77 kB)
737 Soy leghemoglobin preparation from a strain of Pichia pastoris Jul 23, 2018 FDA has no questions (in PDF) (80 kB)
736 Lactobacillus casei subsp. paracasei Lpc-37 Apr 11, 2018 FDA has no questions (in PDF) (73 kB)
735 2’-Fucosyllactose Apr 6, 2018 FDA has no questions (in PDF) (103 kB)
734 Ergothionine May 7, 2018 FDA has no questions (in PDF) (70 kB)
733 Purified steviol glycosides Jan 9, 2018 FDA has no questions (in PDF) (69 kB)
732 Docosahexaenoic acid oil produced in Schizochytrium sp. Pending
731 Docosahexaenoic acid oil produced in Schizochytrium sp. Pending
730 Arachidonic acid oil produced in Mortierella alpina Mar 30, 2018 FDA has no questions (in PDF) (77 kB)
729 Galacto-oligosaccharides Mar 27, 2018 FDA has no questions (in PDF) (112 kB)
728 Phospholipase C from Pseudomonas sp. 62186 produced in Bacillus licheniformis Nov 13, 2017 FDA has no questions (in PDF) (47 kB)
727 Trehalase from Trichoderma reesei produced in Trichoderma reesei Mar 5, 2018 FDA has no questions (in PDF) (61 kB)
726 Phenolic preparation from olive fruit Feb 28, 2018 FDA has no questions (in PDF) (66 kB)
725 Inactivated Bacillus coagulans GBI-30, 6086 Feb 12, 2018 FDA has no questions (in PDF) (52 kB)
724 Preparation containing six bacterial phages specific to shiga-toxin producing Escherichia coli Apr 10, 2018 FDA has no questions (in PDF) (75 kB)
723 Benzalkonium chloride Dec 18, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (41 kB)
722 Lactobacillus plantarum Lp-115 Feb 16, 2018 FDA has no questions (in PDF) (67 kB)
721 Galacto-oligosaccharides Dec 19, 2017 FDA has no questions (in PDF) (69 kB)
720 Rice bran wax Jan 16, 2018 FDA has no questions (in PDF) (73 kB)
719 Orange pomace and enzyme-treated orange pomace Dec 26, 2017 FDA has no questions (in PDF) (66 kB)
718 Calcium acid pyrophosphate Oct 17, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (32 kB)
717 Short-chain fructo-oligosaccharides Feb 13, 2018 FDA has no questions (in PDF) (82 kB)
716 Bovine milk osteopontin Feb 1, 2018 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (32 kB)
715 Rebaudioside D Oct 24, 2017 FDA has no questions (in PDF) (69 kB)
714 Subtilisin from Bacillus amyloliquefaciens produced in Bacillus subtilis Feb 6, 2018 FDA has no questions (in PDF) (53 kB)
713 Hydrolyzed pork cartilage Apr 5, 2018 FDA has no questions (in PDF) (65 kB)
712 Calcium acetate Feb 5, 2018 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (44 kB)
711 Glucan Dec 26, 2017 FDA has no questions (in PDF) (49 kB)
710 Basic methacrylate copolymer Dec 8, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (50 kB)
709 Pyrroloquinoline quinone disodium salt Mar 6, 2018 FDA has no questions (in PDF) (79 kB)
708 Triacylglycerol lipase from Rhizopus oryzae produced in Aspergillus niger Oct 10, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (52 kB)
707 Glucose oxidase from Penicillium produced in Trichoderma reesei Nov 24, 2017 FDA has no questions (in PDF) (51 kB)
706 Siraitia grosvenorii Swingle (Luo Han Guo) fruit extract Aug 17, 2017 FDA has no questions (in PDF) (93 kB)
705 Distarch phosphate Nov 9, 2017 FDA has no questions (in PDF) (63 kB)
704 Corn oil (by-product of ethanol production) Oct 10, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (67 kB)
703 Alpha-glucosidase from Aspergillus niger produced by Trichoderma reesi Nov 9, 2017 FDA has no questions (in PDF) (128 kB)
702 Purified steviol glycosides Sep 28, 2017 FDA has no questions (in PDF) (65 kB)
701 Pyrroloquinoline quinone disodium salt Sep 8, 2017 FDA has no questions (in PDF) (68 kB)
700 Paracoccus carotinifaciens extract containing carotenoids Oct 23, 2017 FDA has no questions; some uses may require a color additive listing (in PDF) (99 kB)
699 Trehalase from Myceliophthora sepedonium produced by Aspergillus niger Nov 13, 2017 FDA has no questions (in PDF) (67 kB)
698 Paramylon isolate from Euglena gracilis Jul 19, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (105 kB)
697 Dried biomass of Euglena gracilis Jul 19, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (105 kB)
696 Dolomite Oct 3, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (53 kB)
695 Dimethyl ether Aug 29, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (46 kB)
694 Pyrroloquinoline quinone disodium salt (PQQ) Sep 28, 2017 FDA has no questions (in PDF) (72 kB)
693 D-psicose Aug 28, 2017 FDA has no questions (in PDF) (97 kB)
692 Quinoa sprout extract Nov 3, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (33 kB)
691 Bacillus coagulans SANK 70258 spore preparation Aug 28, 2017 FDA has no questions (in PDF) (54 kB)
690 Fruit and vegetable vitamin extract Aug 1, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (117 kB)
689 Phospholipase C from Bacillus thuringiensis produced in Bacillus licheniformis Aug 4, 2017 FDA has no questions (in PDF) (54 kB)
688 Sodium thiocyanate Aug 25, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (47 kB)
687 Inulin from Agave tequilana May 8, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (54 kB)
686 Curcumin from turmeric (Curcuma longa L.) Jul 11, 2017 FDA has no questions (in PDF) (152 kB)
685 Lactobacillus plantarum strain 299v Oct 31, 2017 FDA has no questions (in PDF) (44 kB)
684 Mung bean protein isolate Aug 4, 2017 FDA has no questions (in PDF) (119 kB)
683 Canola protein isolate May 10, 2017 FDA has no questions (in PDF) (75 kB)
682 Lecithin from canola Jul 7, 2017 FDA has no questions (in PDF) (151 kB)
681 Dried isomaltulose syrup Jun 21, 2017 FDA has no questions (in PDF) (151 kB)
680 Alpha-L-arabinofuranosidase from Talaromyces pinophilus produced by Trichoderma reesei May 24, 2017 FDA has no questions (in PDF) (101 kB)
679 Dealcoholized fermented orange juice May 10, 2017 FDA has no questions (in PDF) (67 kB)
678 Alpha-cyclodextrin Apr 14, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (49 kB)
677 Docosahexaenoic acid oil produced in Schizochytrium sp. May 2, 2017 FDA has no questions (in PDF) (101 kB)
676 Colicin May 15, 2017 FDA has no questions (in PDF) (90 kB)
675 Xylanase enzyme preparation produced by Trichoderma reesei carrying a xylanase gene from Talaromyces leycettanus Apr 6, 2017 FDA has no questions (in PDF) (76 kB)
674 Isomalto-oligosaccharides Jul 5, 2017 FDA has no questions (in PDF) (160 kB)
673 Algal fat derived from Prototheca moriformis (S7737) Mar 27, 2017 FDA has no questions (in PDF) (76 kB)
672 Preparation containing five bacterial monophages specific to Shigella spp. Mar 27, 2017 FDA has no questions (in PDF) (109 kB)
671 Galacto-oligosaccharides (GOS) Apr 11, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (62 kB)
670 Inactivated Bacillus coagulans GBI-30, 6086 Mar 15, 2017 FDA has no questions (in PDF) (47 kB)
669 Cow’s milk-derived lactoferrin Mar 9, 2017 FDA has no questions (in PDF) (168 kB)
668 Sodium formate Mar 9, 2017 FDA has no questions (in PDF) (106 kB)
667 Rebaudioside M Feb 17, 2017 FDA has no questions (in PDF) (115 kB)
666 Chondroitin sodium sulfate Mar 15, 2017 FDA has no questions (in PDF) (109 kB)
665 Lactoperoxidase system Dec 14, 2016 At the notifier's request, FDA ceased to evaluate this notice
664 Alpha-amylase from Cytophaga sp. expressed in Bacillus licheniformis Jan 31, 2017 FDA has no questions (in PDF) (79 kB)
663 Distarch phosphate Sep 30, 2016 At the notifier's request, FDA ceased to evaluate this notice
662 Glucosylated steviol glycosides (minimum purity 95%) Sep 29, 2016 FDA has no questions
661 Fucus vesiculosus concentrate Feb 10, 2017 FDA has no questions (in PDF) (85 kB)
660 Bacillus coagulans GBI-30, 6086 Jan 13, 2017 FDA has no questions (in PDF) (81 kB)
659 Lacto-N-neotetraose Nov 23, 2016 FDA has no questions
658 Grapefruit extract Sep 28, 2016 At the notifier's request, FDA ceased to evaluate this notice
657 Glucoamylase from Penicillum oxalicum produced in Aspergillus niger Nov 23, 2016 FDA has no questions
656 Enzyme-modified steviol glycosides Sep 28, 2016 FDA has no questions
655 Rice bran wax Sep 20, 2016 At the notifier's request, FDA ceased to evaluate this notice
654 Cocoa butter substitute Dec 19, 2016 FDA has no questions
653 Lysophospholipase from Aspergillus nishimurae expressed in Trichoderma reesei. Oct 13, 2016 FDA has no questions
652 Gamma linolenic acid safflower oil Dec 16, 2016 FDA has no questions
651 Phospholipase A1 from Talaromyces leycettanus produced in Aspergillus niger Nov 23, 2016 FDA has no questions
650 2'-O-fucosyllactose Nov 23, 2016 FDA has no questions
649 β-galactosidase enzyme preparation from Bacillus circulans produced in Bacillus subtilis Nov 28, 2016 FDA has no questions
648 Monoglycerides Dec 13, 2016 FDA has no questions
647 D-psicose Oct 11, 2016 At the notifier's request, FDA ceased to evaluate this notice
646 Pecan shell fiber Oct 12, 2016 FDA has no questions
645 Pullulanase from Bacillus deramificans and Bacillus acidopullulyticus expressed in Bacillus licheniformis Nov 1, 2016 FDA has no questions
644 Non-fat dry goat milk and goat whey protein Oct 11, 2016 FDA has no questions
643 Phosphatidylserine derived from fish Jul 1, 2016 At the notifier's request, FDA ceased to evaluate this notice
642 Camelina oil Oct 12, 2016 FDA has no questions
641 Pyrroloquinoline quinone disodium salt Oct 14, 2016 FDA has no questions
640 Esterified propoxylated glycerol Sep 21, 2016 FDA has no questions
639 Zeaxanthin from marigold Sep 28, 2016 FDA has no questions; some uses may require a color additive listing
638 High purity steviol glycosides (minimum purity 97%) consisting primarily of rebaudioside A Jul 10, 2016 FDA has no questions
637 Phosphatidylserine derived soy lecithin Aug 4, 2016 At the notifier's request, FDA ceased to evaluate this notice
636 Phosphatidylserine derived from sunflower Jul 1, 2016 At the notifier's request, FDA ceased to evaluate this notice
635 Nicotinamide riboside chloride Aug 3, 2016 FDA has no questions
634 Calcium chloride Aug 8, 2016 FDA has no questions
633 Whey protein Sep 21, 2016 FDA has no questions
632 Rebaudioside A from Yarrowia lipolytica Jun 24, 2016 FDA has no questions
631 Triacylglycerol lipase from Fusarium oxysporum produced in Trichoderma reesei Jul 18, 2016 FDA has no questions
630 Preparation containing the bacterial monophages, Fo1a and S16, specific to Salmonella May 17, 2016 At the notifier's request, FDA ceased to evaluate this notice
629 Siraitia grosvenorii Swingle (Luo Han Guo) fruit extract Jul 15, 2016 At the notifier's request, FDA ceased to evaluate this notice
628 endo-1,4-beta-xylanase from Trichoderma reesei Sep 14, 2016 FDA has no questions
627 Siraitia grosvenorii Swingle (Luo Han Guo) fruit juice concentrate Oct 11, 2016 FDA has no questions
626 Steviol glycosides produced in Saccharomyces cerevisiae May 27, 2016 FDA has no questions
625 Pyrroloquinoline quinone disodium salt Aug 18, 2016 FDA has no questions
624 D-allulose 3-epimerase from Arthrobacter globiformis M30 produced in Escherichia coli Aug 18, 2016 FDA has no questions
623 Fructooligosaccharides Aug 1, 2016 FDA has no questions
622 Emulsified fish oil May 13, 2016 At the notifier's request, FDA ceased to evaluate this notice
621 Emulsified algal oil May 13, 2016 At the notifier's request, FDA ceased to evaluate this notice
620 Galacto-oligosaccharides Jul 21, 2016 FDA has no questions
619 Purified steviol glycosides May 27, 2016 FDA has no questions
618 Purified seawater May 27, 2016 FDA has no questions
617 α-amylase from Cytophaga sp. produced in Bacillus licheniformis Apr 8, 2016 At the notifier's request, FDA ceased to evaluate this notice
616 High-amylose cornstarch acetate Jun 24, 2016 FDA has no questions
615 High-amylose cornstarch Jun 24, 2016 FDA has no questions
614