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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


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  • Select the specific GRN number below to view additional details about any GRAS Notice.
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Records Found: 847 Show 50 records at a time
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter
847 Lactobacillus plantarum ECGC 13110402 Pending
846 Rebaudioside M Pending
845 Lactobacillus rhamnosus LGG Pending
844 Algal oil (55% docosahexaenoic acid) from Schizochytrium sp. strain FCC-3204 Pending
843 Algal oil (35% docosahexaenoic acid) from Schizochytrium sp. strain FCC-1324 Pending
842 Maltogenic alpha-amylase Pending
841 Saccharomyces cerevisiae expressing L-lactate dehydrogenase from Rhizopus oryzae Pending
840 Lactobacillus paracasei strain F19 Pending
839 Purified steviol glycosides Pending
838 Purified steviol glycosides Pending
837 Hydroxytyrosol Pending
836 Algal oil (50-60% docosahexaenoic acid) from Schizochytrium sp. HS01 Pending
835 Ilex guayusa leaf extract Pending
834 Preparation containing bacterial phages specific to shiga-toxin producing Escherichia coli Pending
833 Lacto-N-tetraose Pending
832 Acid prolyl endopeptidase produced by Aspergillus niger Pending
831 Bacillus subtilis DE111 Pending
830 Chicory flour Pending
829 Dried biomass of Aspergillus oryzae fermented with minerals Pending
828 D-psicose Pending
827 Preparation containing three bacterial phages specific to several Escherichia coli serotypes Pending
826 Dihydroquercetin Pending
825 Beta-galactosidase from Kluyveromyces lactis Pending
824 Bacteriocin preparations specific to Salmonella Pending
823 Rebaudioside E Pending
822 Curcumin Pending
821 Glucosylated steviol glycosides Pending
820 Lactobacillus fermentum CECT5716 Apr 3, 2019 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (35.2 kB)
819 Fatty acid ethyl esters from Alaskan Pollock Pending
818 Isomalto-oligosaccharides Pending
817 Serine endopeptidase from Malbranchea cinnamomea produced in Trichoderma reesei Pending
816 Xylooligosaccharides from sugarcane Apr 29, 2019 FDA has no questions (in PDF) (160 kB)
815 2'-fucosyllactose and difucosyllactose Pending
814 Bifidobacterium bifidum BGN4 Pending
813 Bifidobacterium longum BORI Pending
812 Rebaudioside M Pending
811 Phospholipase A1 produced by Aspergillus oryzae Pending
810 Lactobacillus paracasei subsp. paracasei strain F-19e Apr 5, 2019 FDA has no questions (in PDF) (178 kB)
809 Fractionated whey protein concentrate containing 41% alphalactalbumin Pending
808 Lipase from Aspergillus tubingensis produced in Trichoderma reesei Pending
807 Streptococcus salivarius M18 Pending
806 Dolomite Pending
805 Apple peel powder Mar 8, 2019 FDA has no questions (in PDF) (522 kB)
804 Pea protein Pending
803 Pea protein Pending
802 Endolysin Pending
801 Chymosin enzyme from Camelus dromedarius produced in Aspergillus niger Pending
800 gamma-oryzanol Mar 8, 2019 FDA has no questions (in PDF) (628 kB)
799 Rebaudioside M Sep 25, 2018 FDA has no questions (in PDF) (112 kB)
798 Saccharomyces cerevisiae strain yBBS002 Pending
797 Fructooligosaccharides Nov 15, 2018 FDA has no questions (in PDF) (454 kB)
796 Orange extract (85% hesperidin) Feb 20, 2019 FDA has no questions (in PDF) (458 kB)
795 Purified steviol glycosides Sep 25, 2018 FDA has no questions (in PDF) (105 kB)
794 Shiitake, pea, and rice protein fermented with Lentinula edodes Nov 9, 2018 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (53 kB)
793 Cultured corn starch fermented by Corynebacterium stationis Apr 26, 2019 FDA has no questions (in PDF) (171 kB)
792 Cultured corn starch fermented by Corynebacterium glutamicum Apr 26, 2019 FDA has no questions (in PDF) (160 kB)
791 Urolithin A Dec 20, 2018 FDA has no questions (in PDF) (145 KB)
790 Steviol glycosides (minimum purity 95%) Feb 26, 2019 FDA has no questions (in PDF) (448 kB)
789 Erythritol Feb 20, 2019 FDA has no questions (in PDF) (79 kB)
788 Pea protein concentrate Oct 12, 2018 FDA has no questions (in PDF) (249 kB)
787 Quinoa sprout powder Sep 9, 2018 FDA has no questions (in PDF) (94 kB)
786 Calcium propionate Nov 20, 2018 FDA has no questions (in PDF) (74 kB)
785 Calcium chloride Nov 20, 2018 FDA has no questions (in PDF) (74 kB)
784 Siraitia grosvenorii Swingle (Luo Han Guo) fruit juice concentrate Nov 20, 2018 FDA has no questions (in PDF) (664 kB)
783 Triacylglycerol lipase from Rhizopus oryzae produced in Aspergillus niger Dec 20, 2018 FDA has no questions (in PDF) (81 kB)
782 L-arabinose Aug 29, 2018 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (47 kB)
781 Alpha-tocopherol (fruit and vegetable derived) Nov 5, 2018 FDA has no questions (in PDF) (1 MB)
780 Rebaudioside M Jul 31, 2018 FDA has no questions (in PDF) (115 kB)
779 Isomalto-oligosaccharide mixture Oct 19, 2018 FDA has no questions (in PDF) (92 kB)
778 Hemp seed oil Dec 20, 2018 FDA has no questions (in PDF) (434 kB)
777 Algal oil (55% docosahexaenoic acid) from Schizochytrium sp. strain FCC-3204 Oct 26, 2018 FDA has no questions (in PDF) (233 kB)
776 Algal oil (35% docosahexaenoic acid) from Schizochytrium sp. strain FCC-1324 Oct 26, 2018 FDA has no questions (in PDF) (573 kB)
775 Colicin preparations Oct 26, 2018 FDA has no questions (in PDF) (80 kB)
774 Glutaminase from Bacillus licheniformis produced in Bacillus licheniformis Nov 26, 2018 FDA has no questions (in PDF) (73 kB)
773 Dried biomass of Chlamydomonas reinhardtii Feb 22, 2019 FDA has no questions (in PDF) (148 kB)
772 Palmitoylated green tea catechins Dec 13, 2018 FDA has no questions (in PDF) (63 KB)
771 Hemp seed protein Dec 20, 2018 FDA has no questions (in PDF) (484 kB)
770 Potassium polyaspartate Sep 11, 2018 FDA has no questions (in PDF) (789 kB)
769 Vitamin C (fruit and vegetable derived) Oct 23, 2018 FDA has no questions (in PDF) (72 kB)
768 Stevia leaf extract Aug 13, 2018 FDA has no questions (in PDF) (100 kB)
767 Polyvinyl alcohol Sep 19, 2018 FDA has no questions (in PDF) (57 kB)
766 3'-sialyllactose sodium salt Sep 26, 2018 FDA has no questions (in PDF) (81 kB)
765 Dehulled hemp seed Dec 20, 2018 FDA has no questions (in PDF) (278 kB)
764 Rebaudioside D Jul 10, 2018 FDA has no questions (in PDF ) (111 kB)
763 Alpha-lactalbumin Dec 10, 2018 FDA has no questions (in PDF) (106 KB)
762 Carnobacterium divergens M35 preparation Aug 14, 2018 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (31 kB)
761 Esterified propoxylated glycerol May 25, 2018 FDA has no questions (in PDF) (105 kB)
760 Lactobacillus curvatus DSM 18775 Jan 29, 2019 FDA has no questions (in PDF) (77 KB)
759 Steviol glycosides consisting primarily of rebaudioside M produced in Yarrowia lipolytica May 25, 2018 FDA has no questions (in PDF) (106 kB)
758 Lactobacillus helveticus R0052, Bifidobacterium longum subsp. infantis R0033, and Bifidobacterium bifidum R0071 Aug 20, 2018 FDA has no questions (in PDF) (103 kB)
757 Preparation containing two bacterial phages specific to Escherichia coli O157 Aug 3, 2018 FDA has no questions (in PDF) (67 kB)
756 Endo-1,4-beta-glucanase from Trichoderma reesei Pending
755 D-psicose May 10, 2018 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (56 kB)
754 Algal oil (87% oleic acid) derived from Prototheca moriformis strain S6697 Jul 23, 2018 FDA has no questions (in PDF) (111 kB)
753 Sodium thiocyanate Jul 31, 2018 FDA has no questions (in PDF) (56 kB)
752 Preparation containing the bacterial monophages, BP-63 and LVR16-A, specific to Salmonella Jul 13, 2018 FDA has no questions (in PDF) (57 kB)
751 Maltogenic alpha-amylase from Bacillus stearothermophilus produced in Bacillus subtilis Jul 31, 2018 FDA has no questions (in PDF) (228 KB)
750 Beta-glucosidase from Aspergillus niger Oct 2, 2018 FDA has no questions (in PDF) (767 KB)
749 2-O-fucosyllactose Apr 23, 2018 FDA has no questions (in PDF) (95 kB)
748 Tomato powder Apr 19, 2018 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (44 kB)
747 Calcium lactate Jun 1, 2018 FDA has no questions (in PDF) (76 kB)
746 Maltogenic amylase from Geobacillus stearothermophilus produced in Bacillus subtilis Jun 13, 2018 FDA has no questions (in PDF) (104 kB)
745 Steviol glycosides consisting primarily of rebaudioside M Apr 20, 2018 FDA has no questions (in PDF) (103 kB)
744 Steviol glycosides consisting primarily of rebaudioside M Mar 23, 2018 FDA has no questions (in PDF) (131 kB)
743 β-galactosidase from Papiliotrema terrestris Jun 1, 2018 FDA has no questions (in PDF) (68 kB)
742 Duckweed (subfamily Lemnoideae) powder Aug 22, 2018 FDA has no questions (in PDF) (64 kB)
741 Dimethyl ether May 18, 2018 FDA has no questions (in PDF) (72 kB)
740 Glycolipids from Dacryopinax spathularia May 17, 2018 FDA has no questions (in PDF) (93 kB)
739 Mannanase enzyme from Talaromyces leycettanus produced in Aspergillus niger Apr 25, 2018 FDA has no questions (in PDF) (113 KB)
738 Thaumatin Apr 18, 2018 FDA has no questions (in PDF) (77 kB)
737 Soy leghemoglobin preparation from a strain of Pichia pastoris Jul 23, 2018 FDA has no questions (in PDF) (80 kB)
736 Lactobacillus casei subsp. paracasei Lpc-37 Apr 11, 2018 FDA has no questions (in PDF) (73 kB)
735 2-Fucosyllactose Apr 6, 2018 FDA has no questions (in PDF) (103 kB)
734 Ergothionine May 7, 2018 FDA has no questions (in PDF) (70 kB)
733 Purified steviol glycosides Jan 9, 2018 FDA has no questions (in PDF) (69 kB)
732 Docosahexaenoic acid oil produced in Schizochytrium sp. Apr 6, 2018 FDA has no questions (in PDF) (68 kB)
731 Docosahexaenoic acid oil produced in Schizochytrium sp. Apr 6, 2018 FDA has no questions (in PDF) (72 kB)
730 Arachidonic-acid rich oil from Mortierella alpina strain LU 166 Mar 30, 2018 FDA has no questions (in PDF) (77 kB)
729 Galacto-oligosaccharides Mar 27, 2018 FDA has no questions (in PDF) (112 kB)
728 Phospholipase C from Pseudomonas sp. 62186 produced in Bacillus licheniformis Nov 13, 2017 FDA has no questions (in PDF) (47 kB)
727 Trehalase from Trichoderma reesei produced in Trichoderma reesei Mar 5, 2018 FDA has no questions (in PDF) (61 kB)
726 Phenolic preparation from olive fruit Feb 28, 2018 FDA has no questions (in PDF) (66 kB)
725 Inactivated Bacillus coagulans GBI-30, 6086 Feb 12, 2018 FDA has no questions (in PDF) (52 kB)
724 Preparation containing six bacterial phages specific to shiga-toxin producing Escherichia coli Apr 10, 2018 FDA has no questions (in PDF) (75 kB)
723 Benzalkonium chloride Dec 18, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (41 kB)
722 Lactobacillus plantarum Lp-115 Feb 16, 2018 FDA has no questions (in PDF) (67 kB)
721 Galacto-oligosaccharides Dec 19, 2017 FDA has no questions (in PDF) (69 kB)
720 Rice bran wax Jan 16, 2018 FDA has no questions (in PDF) (73 kB)
719 Orange pomace and enzyme-treated orange pomace Dec 26, 2017 FDA has no questions (in PDF) (66 kB)
718 Calcium acid pyrophosphate Oct 17, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (32 kB)
717 Short-chain fructo-oligosaccharides Feb 13, 2018 FDA has no questions (in PDF) (82 kB)
716 Bovine milk osteopontin Feb 1, 2018 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (32 kB)
715 Rebaudioside D Oct 24, 2017 FDA has no questions (in PDF) (69 kB)
714 Subtilisin from Bacillus amyloliquefaciens produced in Bacillus subtilis Feb 6, 2018 FDA has no questions (in PDF) (53 kB)
713 Hydrolyzed pork cartilage Apr 5, 2018 FDA has no questions (in PDF) (65 kB)
712 Calcium acetate Feb 5, 2018 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (44 kB)
711 Glucan Dec 26, 2017 FDA has no questions (in PDF) (49 kB)
710 Basic methacrylate copolymer Dec 8, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (50 kB)
709 Pyrroloquinoline quinone disodium salt Mar 6, 2018 FDA has no questions (in PDF) (79 kB)
708 Triacylglycerol lipase from Rhizopus oryzae produced in Aspergillus niger Oct 10, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (52 kB)
707 Glucose oxidase from Penicillium produced in Trichoderma reesei Nov 24, 2017 FDA has no questions (in PDF) (51 kB)
706 Siraitia grosvenorii Swingle (Luo Han Guo) fruit extract Aug 17, 2017 FDA has no questions (in PDF) (93 kB)
705 Distarch phosphate Nov 9, 2017 FDA has no questions (in PDF) (63 kB)
704 Corn oil (by-product of ethanol production) Oct 10, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (67 kB)
703 Alpha-glucosidase from Aspergillus niger produced by Trichoderma reesi Nov 9, 2017 FDA has no questions (in PDF) (128 kB)
702 Purified steviol glycosides Sep 28, 2017 FDA has no questions (in PDF) (65 kB)
701 Pyrroloquinoline quinone disodium salt Sep 8, 2017 FDA has no questions (in PDF) (68 kB)
700 Paracoccus carotinifaciens extract containing carotenoids Oct 23, 2017 FDA has no questions; some uses may require a color additive listing (in PDF) (99 kB)
699 Trehalase from Myceliophthora sepedonium produced by Aspergillus niger Nov 13, 2017 FDA has no questions (in PDF) (67 kB)
698 Paramylon isolate from Euglena gracilis Jul 19, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (105 kB)
697 Dried biomass of Euglena gracilis Jul 19, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (105 kB)
696 Dolomite Oct 3, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (53 kB)
695 Dimethyl ether Aug 29, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (46 kB)
694 Pyrroloquinoline quinone disodium salt (PQQ) Sep 28, 2017 FDA has no questions (in PDF) (72 kB)
693 D-psicose Aug 28, 2017 FDA has no questions (in PDF) (97 kB)
692 Quinoa sprout extract Nov 3, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (33 kB)
691 Bacillus coagulans SANK 70258 spore preparation Aug 28, 2017 FDA has no questions (in PDF) (54 kB)
690 Fruit and vegetable vitamin extract Aug 1, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (117 kB)
689 Phospholipase C from Bacillus thuringiensis produced in Bacillus licheniformis Aug 4, 2017 FDA has no questions (in PDF) (54 kB)
688 Sodium thiocyanate Aug 25, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (47 kB)
687 Inulin from Agave tequilana May 8, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (54 kB)
686 Curcumin from turmeric (Curcuma longa L.) Jul 11, 2017 FDA has no questions (in PDF) (152 kB)
685 Lactobacillus plantarum strain 299v Oct 31, 2017 FDA has no questions (in PDF) (44 kB)
684 Mung bean protein isolate Aug 4, 2017 FDA has no questions (in PDF) (119 kB)
683 Canola protein isolate May 10, 2017 FDA has no questions (in PDF) (75 kB)
682 Lecithin from canola Jul 7, 2017 FDA has no questions (in PDF) (151 kB)
681 Dried isomaltulose syrup Jun 21, 2017 FDA has no questions (in PDF) (151 kB)
680 Alpha-L-arabinofuranosidase from Talaromyces pinophilus produced by Trichoderma reesei May 24, 2017 FDA has no questions (in PDF) (101 kB)
679 Orange juice desugared by fermentation May 10, 2017 FDA has no questions (in PDF) (67 kB)
678 Alpha-cyclodextrin Apr 14, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (49 kB)
677 Docosahexaenoic acid oil produced in Schizochytrium sp. May 2, 2017 FDA has no questions (in PDF) (101 kB)
676 Colicin preparations May 15, 2017 FDA has no questions (in PDF) (90 kB)
675 Xylanase enzyme preparation produced by Trichoderma reesei carrying a xylanase gene from Talaromyces leycettanus Apr 6, 2017 FDA has no questions (in PDF) (76 kB)
674 Isomalto-oligosaccharides Jul 5, 2017 FDA has no questions (in PDF) (160 kB)
673 Algal fat derived from Prototheca moriformis (S7737) Mar 27, 2017 FDA has no questions (in PDF) (76 kB)
672 Preparation containing five bacterial monophages specific to Shigella spp. Mar 27, 2017 FDA has no questions (in PDF) (109 kB)
671 Galacto-oligosaccharides (GOS) Apr 11, 2017 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (62 kB)
670 Inactivated Bacillus coagulans GBI-30, 6086 Mar 15, 2017 FDA has no questions (in PDF) (47 kB)
669 Cows milk-derived lactoferrin Mar 9, 2017 FDA has no questions (in PDF) (168 kB)
668 Sodium formate Mar 9, 2017 FDA has no questions (in PDF) (106 kB)
667 Rebaudioside M Feb 17, 2017 FDA has no questions (in PDF) (115 kB)
666 Chondroitin sulfate sodium Mar 15, 2017 FDA has no questions (in PDF) (109 kB)
665 Lactoperoxidase system Dec 14, 2016 At the notifier's request, FDA ceased to evaluate this notice
664 Alpha-amylase from Cytophaga sp. expressed in Bacillus licheniformis Jan 31, 2017 FDA has no questions (in PDF) (79 kB)
663 Distarch phosphate Sep 30, 2016 At the notifier's request, FDA ceased to evaluate this notice
662 Glucosylated steviol glycosides (minimum purity 95%) Sep 29, 2016 FDA has no questions
661 Fucoidan concentrate from Fucus vesiculosus Feb 10, 2017 FDA has no questions (in PDF) (85 kB)
660 Bacillus coagulans GBI-30, 6086 spores Jan 13, 2017 FDA has no questions (in PDF) (81 kB)
659 Lacto-N-neotetraose Nov 23, 2016 FDA has no questions
658 Grapefruit extract Sep 28, 2016 At the notifier's request, FDA ceased to evaluate this notice
657 Glucoamylase from Penicillum oxalicum produced in Aspergillus niger Nov 23, 2016 FDA has no questions
656 Enzyme-modified steviol glycosides Sep 28, 2016 FDA has no questions
655 Rice bran wax Sep 20, 2016 At the notifier's request, FDA ceased to evaluate this notice
654 Cocoa butter substitute manufactured using palm oil stearin and stearic acid Dec 19, 2016 FDA has no questions
653 Lysophospholipase from Aspergillus nishimurae expressed in Trichoderma reesei. Oct 13, 2016 FDA has no questions
652 Gamma linolenic acid safflower oil Dec 16, 2016 FDA has no questions
651 Phospholipase A1 from Talaromyces leycettanus produced in Aspergillus niger Nov 23, 2016 FDA has no questions
650 2'-O-fucosyllactose Nov 23, 2016 FDA has no questions
649 β-galactosidase enzyme preparation from Bacillus circulans produced in Bacillus subtilis Nov 28, 2016 FDA has no questions
648 Monoglycerides Dec 13, 2016 FDA has no questions
647 D-psicose Oct 11, 2016 At the notifier's request, FDA ceased to evaluate this notice
646 Pecan shell fiber Oct 12, 2016