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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


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  • Select the specific GRN number below to view additional details about any GRAS Notice.
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Records Found: 859 Show All Page 1 of 18
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter
859 2'-fucosyllactose Pending
858 Glucosylated steviol glycosides Pending
857 Phospholipase A1 produced by Aspergillus niger Pending
856 Bifidobacterium animalis ssp. lactis strain BB-12 Pending
855 Bifidobacterium animalis ssp. lactis strain R0421 Pending
854 Inulin from Agave tequilana Pending
853 Lysozyme produced by Trichoderma reesei Pending
852 2’-fucosyllactose Pending
851 Pea protein Pending
850 Shea olein Pending
849 Inulin from artichoke Pending
848 Pea and rice protein fermented by Shitake mycelia Pending
847 Lactobacillus plantarum ECGC 13110402 Pending
846 Rebaudioside M Pending
845 Lactobacillus rhamnosus LGG Pending
844 Algal oil (55% docosahexaenoic acid) from Schizochytrium sp. strain FCC-3204 Pending
843 Algal oil (35% docosahexaenoic acid) from Schizochytrium sp. strain FCC-1324 Pending
842 Maltogenic alpha-amylase Pending
841 Saccharomyces cerevisiae expressing L-lactate dehydrogenase from Rhizopus oryzae Pending
840 Lactobacillus paracasei strain F19 Pending
839 Purified steviol glycosides Pending
838 Purified steviol glycosides Pending
837 Hydroxytyrosol Jun 5, 2019 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (54 kB)
836 Algal oil (50-60% docosahexaenoic acid) from Schizochytrium sp. HS01 Pending
835 Ilex guayusa leaf extract May 22, 2019 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (35 kB)
834 Preparation containing bacterial phages specific to shiga-toxin producing Escherichia coli Pending
833 Lacto-N-tetraose Pending
832 Acid prolyl endopeptidase produced by Aspergillus niger Pending
831 Bacillus subtilis DE111 Pending
830 Chicory flour May 22, 2019 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (54 kB)
829 Dried biomass of Aspergillus oryzae fermented with minerals Pending
828 D-psicose Pending
827 Preparation containing three bacterial phages specific to several Escherichia coli serotypes Pending
826 Dihydroquercetin Pending
825 Beta-galactosidase from Kluyveromyces lactis Pending
824 Bacteriocin preparations specific to Salmonella Pending
823 Rebaudioside E Jun 21, 2019 FDA has no questions (in PDF) (757 kB)
822 Curcumin Jun 4, 2019 FDA has no questions (in PDF) (861 kB)
821 Glucosylated steviol glycosides May 7, 2019 FDA has no questions (in PDF) (743 kB)
820 Lactobacillus fermentum CECT5716 Apr 3, 2019 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (35.2 kB)
819 Fatty acid ethyl esters from Alaskan Pollock Pending
818 Isomalto-oligosaccharides Pending
817 Serine endopeptidase from Malbranchea cinnamomea produced in Trichoderma reesei Pending
816 Xylooligosaccharides from sugarcane Apr 29, 2019 FDA has no questions (in PDF) (160 kB)
815 2'-fucosyllactose and difucosyllactose Pending
814 Bifidobacterium bifidum BGN4 Jun 25, 2019 FDA has no questions (in PDF) (78 kB)
813 Bifidobacterium longum BORI Pending
812 Rebaudioside M Dec 8, 2018 FDA has no questions (in PDF) (659 kB)
811 Phospholipase A1 produced by Aspergillus oryzae Pending
810 Lactobacillus paracasei subsp. paracasei strain F-19e Apr 5, 2019 FDA has no questions (in PDF) (178 kB)

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GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter

679663  

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