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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.

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  • Select the specific GRN number below to view additional details about any GRAS Notice.
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Records Found: 847 Show All Page 1 of 17
(sorted Z-A)
Substance Date of closure FDA's Letter
847 Lactobacillus plantarum ECGC 13110402 Pending
846 Rebaudioside M Pending
845 Lactobacillus rhamnosus LGG Pending
844 Algal oil (55% docosahexaenoic acid) from Schizochytrium sp. strain FCC-3204 Pending
843 Algal oil (35% docosahexaenoic acid) from Schizochytrium sp. strain FCC-1324 Pending
842 Maltogenic alpha-amylase Pending
841 Saccharomyces cerevisiae expressing L-lactate dehydrogenase from Rhizopus oryzae Pending
840 Lactobacillus paracasei strain F19 Pending
839 Purified steviol glycosides Pending
838 Purified steviol glycosides Pending
837 Hydroxytyrosol Pending
836 Algal oil (50-60% docosahexaenoic acid) from Schizochytrium sp. HS01 Pending
835 Ilex guayusa leaf extract Pending
834 Preparation containing bacterial phages specific to shiga-toxin producing Escherichia coli Pending
833 Lacto-N-tetraose Pending
832 Acid prolyl endopeptidase produced by Aspergillus niger Pending
831 Bacillus subtilis DE111 Pending
830 Chicory flour Pending
829 Dried biomass of Aspergillus oryzae fermented with minerals Pending
828 D-psicose Pending
827 Preparation containing three bacterial phages specific to several Escherichia coli serotypes Pending
826 Dihydroquercetin Pending
825 Beta-galactosidase from Kluyveromyces lactis Pending
824 Bacteriocin preparations specific to Salmonella Pending
823 Rebaudioside E Pending
822 Curcumin Pending
821 Glucosylated steviol glycosides Pending
820 Lactobacillus fermentum CECT5716 Apr 3, 2019 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (35.2 kB)
819 Fatty acid ethyl esters from Alaskan Pollock Pending
818 Isomalto-oligosaccharides Pending
817 Serine endopeptidase from Malbranchea cinnamomea produced in Trichoderma reesei Pending
816 Xylooligosaccharides from sugarcane Apr 29, 2019 FDA has no questions (in PDF) (160 kB)
815 2'-fucosyllactose and difucosyllactose Pending
814 Bifidobacterium bifidum BGN4 Pending
813 Bifidobacterium longum BORI Pending
812 Rebaudioside M Pending
811 Phospholipase A1 produced by Aspergillus oryzae Pending
810 Lactobacillus paracasei subsp. paracasei strain F-19e Apr 5, 2019 FDA has no questions (in PDF) (178 kB)
809 Fractionated whey protein concentrate containing 41% alphalactalbumin Pending
808 Lipase from Aspergillus tubingensis produced in Trichoderma reesei Pending
807 Streptococcus salivarius M18 Pending
806 Dolomite Pending
805 Apple peel powder Mar 8, 2019 FDA has no questions (in PDF) (522 kB)
804 Pea protein Pending
803 Pea protein Pending
802 Endolysin Pending
801 Chymosin enzyme from Camelus dromedarius produced in Aspergillus niger Pending
800 gamma-oryzanol Mar 8, 2019 FDA has no questions (in PDF) (628 kB)
799 Rebaudioside M Sep 25, 2018 FDA has no questions (in PDF) (112 kB)
798 Saccharomyces cerevisiae strain yBBS002 Pending

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(sorted Z-A)
Substance Date of closure FDA's Letter