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U.S. Department of Health and Human Services

FDA Poisonous Plant Database

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AUTHOR(S): Eickholt, T. H.; Box, R. H.
TITLE: Toxicities of peppermint and Pycnanthemum albescens oils, fam. Labiateae.
YEAR: 1965 CITATION: J Pharm Sci, 54(7), 1071-7072 [English]
FDA #: F19534
ABSTRACT: Abstract: The oral LD50 of peppermint oil U.S.P. in fasted Wistar male rats using death after 24 hr. as the end point was found to be 4441 ± 653 mg/kg. After 48 hr, the oral LD50 was 2426 ± 329 mg/kg. The intraperitoneal LD50 of peppermint oil U.S.P. in Wistar male rats similarly after 24 hr. was determined to be 819 ± 126 mg/kg. This latter was compared with a similar volatile oil, Pycnanthemem albescens. It was found to have an intraperitoneal LD50 in male Wistar rats similarly after 24 hr of 1383 ± 172 mg/kg, which was only approximately 60% as toxic as peppermint oil U.S.P. The oral LD50 of P. albescens oil in fasted Wistar male rats afer 24 hr was 5309 ± 818 mg/kg. After 48 hr, the oral LD50 was 3147 ± 362 mg/kg.
GRIN #: 400087 Exit Disclaimer
COMMON NAME: peppermint
STANDARD COMMON NAME: peppermint
FAMILYLamiaceae
LATIN NAME
STANDARD PLANT NAMEMentha ×piperita L. nothosubsp. piperita
GRIN #: 314783 Exit Disclaimer
COMMON NAME
STANDARD COMMON NAME
FAMILYLamiaceae
LATIN NAMEPycnanthemum albescens
STANDARD PLANT NAMEPycnanthemum albescens Torr. & A. Gray
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