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U.S. Department of Health and Human Services

FDA Poisonous Plant Database

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AUTHOR(S): Eun, H. C.; Lee, A. Y.
TITLE: Contact dermatitis due to madecassol.
YEAR: 1985 CITATION: Contact Dermatitis, 13(5), 310-313 [English]
FDA #: F09265
ABSTRACT: Case Reports: Madecassol is an extract of Centella asiatica, a member of the Umbelliferae family. It contains madecassic acid, asiatic acid and asiaticoside. It has been used as a wound healing agent and for the prevention of cicatrization. We report contact dermatitis due to Madecassol and a control study with its individual ingredients. Case 1: A 33-year-old female had applied Madecassol ointment on a keloid which occurred 10 years ago. She noted erythema with itching at the site 10 days after application. On examination, mild eczematous lesions were observed on the keloid area. She was patch tested with the Hollister-Stier standard battery, a vehicle series, Madecassol (as is) and TECA (titrated extract of Centela asiatica) 10% and 1%. She showed a ++ positive reaction only to Madecassol. Case 2: A 23-year-old female had applied Madecassol ointment for the prevention of hypertrophic scarring on the donor site of her skin graft. Itchy oozing erythematous lesions appeared on the graft site a few weeks after application. She was patch tested with the Hollister-Stier standard battery, various antiseptics used, Madecassol (as is) and its individual ingredients. She showed positive reactions to Madecassol, 10% TECA (titrated extract of Centella asiatica), propylene glycol (20%, 30%, 40%, and 50%) and geranium oil 20%. Case 3: A 26-year-old female had applied Madecassol ointment on her skin graft area as in Case 2. An erythematous papular eruption with itching was observed on her graft area 2-3 weeks after application. She showed a strong positive reaction to Madecassol only on patch testing. Case 4: An 18-year-old female had applied Madecassol ointment on a burn scar. 4 days later, itching and erythema lesions were observed at the site. She showed positive reactions to Madecassol, 10% TECA and propylene glycol (5%, 10%, 20%, 30%, 40% and 50%). Control Study and the Results: 63 normal adults were patch tested with Madecassol (as is), propylene glycol of different concentrations, TECA, asiaticoside and free genin (asiatic acid + madecassic acid), which are the components of Madecassol. 12.7% positive reactions were observed to Madecassol , and 9.5% to 1.6% reactions to propylene glycol according to the concentrations (cases with + reaction, ICDRG criteria). The active ingredients of Madecassol such as TECA, asiaticoside and free genin showed positive reactions in several normal controls, which suggested irritant reactions.
GRIN #: 9831 Exit Disclaimer
COMMON NAME: madecassol
STANDARD COMMON NAME: gotu kola
FAMILYAraliaceae
LATIN NAMECentella asiatica
STANDARD PLANT NAMECentella asiatica (L.) Urb.
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