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U.S. Department of Health and Human Services

FDA Poisonous Plant Database

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AUTHOR(S): Garcia, F.
TITLE: The cathartic effects in man of the leaves of Wikstroemia ovata Meyer (salago leaves).
YEAR: 1933 CITATION: Philippine J Sci, 51(), 485-494 [English]
FDA #: F08807
ABSTRACT: summary: 1. The green leaves of Wikstroemia ovata Meyer (salago leaves) when chewed and swallowed produced varying degrees of catharsis, depending upon the number of leaves taken. In general it may be stated that every large leaf caused one watery bowel movement.2. One to two large leaves of "salago" chewed and swallowed, caused generally one to two laxative or purgative effects, and three to four leaves, weighing from 0.4 to 0.6 gram produced three to four water stools apparently drastic in character. The therapeutic cathartic doses may be placed between one and four leaves, inclusive, or 0.15 to 0.65 gram. Five large leaves, weighing at least 0.8 gram, produced not only catharsis but in some cases vomiting and other pronounced side effects.3. The side effects noted were the effects on the mouth and throat when leaves were masticated and consisted of a warm to burning sensation and pungent and biting taste, mingled, later, with numbness. These effects were intensified in two to three hours and then gradually subsided in ten to sixteen hours. Eructation and flatus frequently occurred in one to two hours or more before the cathartic effect. Sensation of fullness in the abdomen, slight abdominal pain occurring at intervals, mild tenesmus, perspiration, and bodily weakness were the frequent complaints of the subjects.4. The undesirable effects on the mouth and throat could be avoided by administration of the leaves in capsules, but in this form of administration the cathartic effects were uncertain. The abdominal pain and tenesmus were apparently not mitigated by the administration of therapeutic dose of belladonna.5. The cathartic active principle was partly or mainly lost during desiccation at room temperature and in keeping the leaves in the dried form. some of it was still left after two years, enough to give distinctly the usual effect on the mouth when chewed, but not enough to produce catharsis as when freshly taken. The deterioration of the active principle in drying and keeping rendered the chemical and pharmacodynamic studies difficult on account of the lack of fresh material when needed.
GRIN #: 418523 Exit Disclaimer
LATIN NAMEWikstroemia ovata Meyer
STANDARD PLANT NAMEWikstroemia ovata C. A. Mey.