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U.S. Department of Health and Human Services

Scientific Publications by FDA Staff

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Infect Immun 2006 Mar;74(3):1949-53

Routine markerless gene replacement in Bacillus anthracis.

Janes BK, Stibitz S

Stibitz S, US FDA, Ctr Biol Evaluat & Res, Div Bacterial Prod, 8800 Rockville Pike, Bethesda, MD 20892 USA US FDA, Div Bacterial Parasit & Allergen Prod, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA


An improved genetic tool suitable for routine markerless allelic exchange in Bacillus anthracis has been constructed. Its utility was demonstrated by the introduction of insertions, deletions, and missense mutations on the chromosome and plasmid pXO1 of the Sterne strain of B. anthracis.

Category: Journal Article
PubMed ID: #16495572
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2011-10-04 Entry Last Modified: 2012-08-29