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Mucosal Immunol 2010 Sep;3(5):496-505

Progesterone regulation of uterine dendritic cell function in rodents is dependent on the stage of estrous cycle.

Butts CL, Candando KM, Warfel J, Belyavskaya E, D'Agnillo F, Sternberg EM


Steroid hormones, such as progesterone, are able to modify immunity and influence disease outcome. Dendritic cells (DCs) drive potent immune responses, express receptors for steroid hormones, and may be a primary target of steroid hormone actions during infection of the genital tract, including uterine tissue. Here, we report that progesterone limited DC-associated activation marker expression and inhibited cytokine secretion by uterine DCs, which was associated with changes in signal transducer and activator of transcription 1 (STAT1) activity. We also found that DCs from mice at stages with higher progesterone concentrations (diestrus, metaestrus) were more sensitive to progesterone than those in stages with lower progesterone concentrations (proestrus, estrus), both in vitro and in vivo. This difference correlated with the levels of progesterone receptor expressed by DCs. These data suggest that progesterone regulates DC function and could contribute to the susceptibility of females to uterine and other genital tract infections at selected time periods throughout the life cycle.

Category: Journal Article
PubMed ID: #20505661 DOI: 10.1038/mi.2010.28
Includes FDA Authors from Scientific Area(s): Biologics, Drugs
Entry Created: 2011-10-04 Entry Last Modified: 2012-08-29