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U.S. Department of Health and Human Services

Scientific Publications by FDA Staff

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Cold Spring Harb Perspect Med 2013 Jun 1;3(6):a013433

Cell-Free Hemoglobin and Its Scavenger Proteins: New Disease Models Leading the Way to Targeted Therapies.

Schaer DJ, Buehler PW


Hemoglobin (Hb) has multiple pathophysiologic effects when released into the intravascular space during hemolysis. The extracellular effects of Hb have resulted in novel models of toxicity, which help to explain endothelial dysfunction and cardiovascular complications that accompany genetic hemolytic anemias, malaria, blood transfusion, and atherosclerosis. The majority of models focus on nitric oxide (NO) depletion; however, in local tissue environments, Hb can also act as a pro-oxidant and inflammatory agent. This can alter cellular differentiation with the potential to deviate immune responses. The understanding of these mechanisms set in the context of natural scavenger and detoxification systems may accelerate the development of novel treatment strategies.

Category: Journal Article
PubMed ID: #23645855 DOI: 10.1101/cshperspect.a013433
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2012-08-27 Entry Last Modified: 2013-12-21