Scientific Publications by FDA Staff

J Virol 2013 Apr;87(8):4772-7

The Frequency of CD127+ HCV-specific T cells but not the Expression of Exhaustion Markers Predict the Outcome of Acute Hepatitis C Virus Infection.

Shin EC, Park SH, Nascimbeni M, Major M, Caggiari L, de Re V, Feinstone SM, Rice CM, Rehermann B

T cells are exhausted and overexpress inhibitory molecules in chronic hepatitis C virus infection. It is unclear whether this is the cause or consequence of HCV persistence. Studying serial blood and liver samples of chimpanzees during acute infection, we demonstrate that the early expression of the memory precursor marker CD127 on HCV-specific T-cells, but not the expression of inhibitory molecules on those T-cells or their ligands in the liver, predict the outcome of acute infection.