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Vox Sang 1976 Nov;31(5):332-6

Detection of an antigen in albumin subjected to repeated heating.

Cohen P, Roelands JF


Stabilized 5 and 25% normal serum albumin (human) derived from plasma, placentas and plasma-placental blends was subjected to repeated heating at 56 degrees C for 120 h, interspersed with storage at 4 degrees C for 48 h. Immunoelectrophoretic analyses showed that after the ninth heating, 5% plasma albumin developed a component which migrated in the alpha-globulin region and gave a reaction of nonidentity with albumin. This antigen, which was not detected in the other albumin samples, reacted with antiserum prepared against control 5% plasma albumin, indicating that it was present in the latter at an undetectably low concentration.

Category: Journal Article
PubMed ID: #1007155 DOI: 10.1111/j.1423-0410.1976.tb04656.x
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2012-11-29