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U.S. Department of Health and Human Services

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Transfusion 1980 Jan-Feb;20(1):90-2

Levels of anti-A and anti-B in commercial immune globulins.

Gordon JM, Cohen P, Finlayson JS


Samples from 168 lots of immune serum globulin, tetanus immune globulin, and Rho (D) immune globulin produced by seven American manufacturers during the period 1973-1977 were analyzed for anti-A and anti-B content by saline and antiglobulin titration. There was appreciable variation among manufacturers, but between 1973 and 1975 all products showed a significant decrease in alloantibody titer. This trend did not continue during the interval 1975-1977; the titers of most manufacturers' products remained near the 1975 level. The anti-A titer of a given product was approximately one dilution higher than the anti-B; both titers were usually increased by anti-human serum, though this occurred more often in the case of anti-B.

Category: Journal Article
PubMed ID: #6986683 DOI: 10.1046/j.1537-2995.1980.20180125049.x
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2012-12-05