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U.S. Department of Health and Human Services

Scientific Publications by FDA Staff

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Photochem Photobiol 1981 Dec;34(6):741-3

Ultraviolet radiation induced changes in macrophage activity.

Schuller GB, Hellman KB


The effect of ultraviolet (UV) radiation on macrophage activity was examined. Thioglycollate-stimulated peritoneal exudate cells were collected from adult C57BL/6 mice. Ninety-five per cent of the cells adhering to plastic petri dishes were macrophages as determined by the presence of a non-specific esterase. Adherent cells were exposed to UV radiation of 0.5-13.2 J/m2. Viability and phagocytosis were measured at 0, 24, 48, 72 and 96 h after exposure. A statistically significant UV exposure-dependent decrease in macrophage viability and phagocytic capacity was observed. Macrophage viability and phagocytosis also decreased as a function of time after exposure to UV radiation.

Category: Journal Article
PubMed ID: #7312958 DOI: 10.1111/j.1751-1097.1981.tb09072.x
Includes FDA Authors from Scientific Area(s): Medical Devices
Entry Created: 2012-12-09