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U.S. Department of Health and Human Services

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Fett/Lipid 1999 Aug;101(8):277-82

Variations in isomer distribution in commercially available conjugated linoleic acid

Yurawecz MP, Sehat N, Mossoba MM, Roach JAG, Kramer JKG, Ku Y


Conjugated linoleic acid (CLA) has been reported to have anticarcinogenic and antiatherogenic properties, to repartition body fat, to build bone mass, to normalize glucose tolerance, and to reduce hyperglycemia and diabetes. CLA products are now commercially available, and there is considerable interest in studying CLA because of this range of reported beneficial effects. However, little is known about the composition of these preparations. Representative commercial CLA products in capsule or liquid (aqueous or oily) form were analyzed for their CLA content and isomer composition using gas chromatography (GC), silver ion-high performance liquid chromatography (Ag+-HPLC) and spectroscopic techniques. The content of CLA in the preparations varied widely. Based on the GC-internal standard technique, total CLA varied from 20 to 89% by total weight and 28 to 94% of total fat. One product contained no CLA. The isomer distributions were generally of two types: those with two major CLA positional isomers, and those with four major CLA positional isomers. All the CLA preparations in capsule form contained the four isomer mixture, while the liquid preparations contained from two to four CLA positional isomers.

Category: Journal Article
DOI: 10.1002/(SICI)1521-4133(199908)101:8<277::AID-LIPI277>3.0.CO;2-C
Includes FDA Authors from Scientific Area(s): Food
Entry Created: 2012-12-29