Scientific Publications by FDA Staff

Clin Vaccine Immunol 2013 Aug;20(8):1338-40

Immunogenicity analysis of Staphylococcus aureus clumping factor A genetic variants.

Brady RA, Mocca CP, Burns DL

The staphylococcal adhesin ClfA has a variant amino acid sequence, generating the potential for alterations in epitope structure and immunogenicity of this vaccine candidate. We demonstrated, for two recombinant ClfA40-531 genetic variants, that strain-specific epitopes are immunodominant. This work indicates that immune responses elicited by ClfA may, at least in part, be dependent on the strain of origin of the ClfA.