• Decrease font size
  • Return font size to normal
  • Increase font size
U.S. Department of Health and Human Services

Scientific Publications by FDA Staff

  • Print
  • Share
  • E-mail

Search Publications



Starting Date

Ending Date

Order by

Entry Details

Clin Vaccine Immunol 2013 Aug;20(8):1338-40

Immunogenicity analysis of Staphylococcus aureus clumping factor A genetic variants.

Brady RA, Mocca CP, Burns DL


The staphylococcal adhesin ClfA has a variant amino acid sequence, generating the potential for alterations in epitope structure and immunogenicity of this vaccine candidate. We demonstrated, for two recombinant ClfA40-531 genetic variants, that strain-specific epitopes are immunodominant. This work indicates that immune responses elicited by ClfA may, at least in part, be dependent on the strain of origin of the ClfA.

Category: Journal Article
PubMed ID: #23803901 DOI: 10.1128/CVI.00275-13
PubMed Central ID: #PMC3754511
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2013-04-19 Entry Last Modified: 2014-02-14