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Magn Reson Med 2014 Jul;72(1):41-8

A dialyzer-based flow system for validating dynamic contrast enhanced MR image acquisition.

Rajan S, Herbertson L, Bernardo M, Choyke P


PURPOSE: Dynamic contrast enhanced magnetic resonance imaging (MRI) has proven to be quite sensitive for the characterization of masses and early response to therapy. However, it is fraught with a number of procedural challenges as well as a lack of standardization. In this article, we describe the use of a simple dialyzer-based flow system to evaluate reproducibility of dynamic contrast enhanced MRI under active flow conditions. METHODS: The MR signal during a bolus injection of Gd-DTPA was analyzed to test the precision and variability of contrast agent kinetics during a typical dynamic contrast enhanced MRI sequence. A simple model allows an estimation of the washout rate constant of Gd-DTPA through the polysulfone tubules of the dialyzer. RESULTS: The simple flow phantom described here provided reproducible measurements of the washout rate constants. The washout rate increased from 0.20 +/- 0.005 min-1 to 0.25 +/- 0.008 min-1 over 32 weeks. Measurements were also made at week 24 using dynamic computed tomography and found to be 0.27 +/- 0.006 min-1 . Overall, the computed tomography derived rate constants results were found be approximately 12% higher than the corresponding MRI values. CONCLUSION: In this study, we show that a simple dialyzer-based flow phantom can be used for testing dynamic contrast enhanced MRI pulse sequences and also allows for short-term reproducibility testing of rate constants.

Category: Journal Article
PubMed ID: #23907806 DOI: 10.1002/mrm.24887
Includes FDA Authors from Scientific Area(s): Medical Devices
Entry Created: 2013-08-03 Entry Last Modified: 2016-03-21