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U.S. Department of Health and Human Services

Scientific Publications by FDA Staff

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J Food Drug Anal 2014 Mar;22(1):49-63

Electron spin resonance spectroscopy for the study of nanomaterial-mediated generation of reactive oxygen species.

He W, Liu Y, Wamer WG, Yin JJ


Many of the biological applications and effects of nanomaterials are attributed to their ability to facilitate the generation of reactive oxygen species (ROS). Electron spin resonance (ESR) spectroscopy is a direct and reliable method to identify and quantify free radicals in both chemical and biological environments. In this review, we discuss the use of ESR spectroscopy to study ROS generation mediated by nanomaterials, which have various applications in biological, chemical, and materials science. In addition to introducing the theory of ESR, we present some modifications of the method such as spin trapping and spin labeling, which ultimately aid in the detection of short-lived free radicals. The capability of metal nanoparticles in mediating ROS generation and the related mechanisms are also presented.

Category: Journal Article, Review
PubMed ID: #24673903 DOI: 10.1016/j.jfda.2014.01.004
Includes FDA Authors from Scientific Area(s): Food
Entry Created: 2014-03-29 Entry Last Modified: 2014-12-17