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U.S. Department of Health and Human Services

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J Virol 2014 Dec 31 [Epub ahead of print]

Impact of natural IgM concentration on gene therapy with adenovirus type 5 vectors.

Qiu Q, Xu Z, Tian J, Moitra R, Gunti S, Notkins AL, Byrnes AP


Natural IgM inhibits gene transfer by type 5 adenovirus (Ad5) vectors. We show that polyreactive natural IgM antibodies bind to Ad5 and that inhibition of liver transduction by IgM depends on Kupffer cells. By manipulating IgM concentration in vivo, we demonstrate that IgM inhibits liver transduction in a concentration-dependent manner. We further show that differences in natural IgM between BALB/c and C57BL/6 mice contribute to lower efficiency of Ad5 gene transfer in BALB/c mice.

Category: Journal Article
PubMed ID: #25552715 DOI: 10.1128/JVI.03217-14
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2014-11-12 Entry Last Modified: 2015-01-02