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U.S. Department of Health and Human Services

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Viruses 2016 Apr 12;8(4):96

Current approaches for diagnosis of influenza virus infections in humans.

Vemula SV, Zhao J, Liu J, Wang X, Biswas S, Hewlett I


Despite significant advancement in vaccine and virus research, influenza continues to be a major public health concern. Each year in the United States of America, influenza viruses are responsible for seasonal epidemics resulting in over 200,000 hospitalizations and 30,000-50,000 deaths. Accurate and early diagnosis of influenza viral infections are critical for rapid initiation of antiviral therapy to reduce influenza related morbidity and mortality both during seasonal epidemics and pandemics. Several different approaches are currently available for diagnosis of influenza infections in humans. These include viral isolation in cell culture, immunofluorescence assays, nucleic acid amplification tests, immunochromatography-based rapid diagnostic tests, etc. Newer diagnostic approaches are being developed to overcome the limitations associated with some of the conventional detection methods. This review discusses diagnostic approaches currently available for detection of influenza viruses in humans.

Category: Journal Article, Review
PubMed ID: #27077877 DOI: 10.3390/v8040096
PubMed Central ID: #PMC4848591
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2015-01-15 Entry Last Modified: 2016-12-20