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Data Brief 2015 Nov 1;5:864-70

The proteomic dataset for bone marrow derived human mesenchymal stromal cells: effect of in vitro passaging.

Mindaye ST, Lo Surdo J, Bauer SR, Alterman MA


Bone-marrow derived mesenchymal stromal cells (BMSCs) have been in clinical trials for therapy. One major bottleneck in the advancement of BMSC-based products is the challenge associated with cell isolation, characterization, and ensuring cell fitness over the course of in vitro cell propagation steps. The data in this report is part of publications that explored the proteomic changes following in vitro passaging of BMSCs [4] and the molecular heterogeneity in cultures obtained from different human donors [5], [6].The methodological details involving cell manufacturing, proteome harvesting, protein identification and quantification as well as the bioinformatic analyses were described to ensure reproducibility of the results.

Category: Journal Article
PubMed ID: #26702413 DOI: 10.1016/j.dib.2015.10.020
PubMed Central ID: #PMC4669433
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2016-02-19