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U.S. Department of Health and Human Services

Scientific Publications by FDA Staff

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Vaccines 2018 Apr 27;6(2):24

Development and regulation of novel influenza virus vaccines: a United States young scientist perspective.

Khurana S


Vaccination against influenza is the most effective approach for reducing influenza morbidity and mortality. However, influenza vaccines are unique among all licensed vaccines as they are updated and administered annually to antigenically match the vaccine strains and currently circulating influenza strains. Vaccine efficacy of each selected influenza virus vaccine varies depending on the antigenic match between circulating strains and vaccine strains, as well as the age and health status of the vaccine recipient. Low vaccine effectiveness of seasonal influenza vaccines in recent years provides an impetus to improve current seasonal influenza vaccines, and for development of next-generation influenza vaccines that can provide broader, long-lasting protection against both matching and antigenically diverse influenza strains. This review discusses a perspective on some of the issues and formidable challenges facing the development and regulation of the next-generation influenza vaccines.

Category: Journal Article, Editorial
PubMed ID: #29702547 DOI: 10.3390/vaccines6020024
PubMed Central ID: #PMC6027304
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2018-04-08 Entry Last Modified: 2018-09-23