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Open Forum Infect Dis 2019 May;6(5):ofz175

Prevalence and impact of hepatitis E virus infection among persons with chronic hepatitis B living in the US and Canada.

McGivern DR, Lin HHS, Wang J, Benzine T, Janssen HJA, Khalili M, Lisker-Melman M, Fontana RJ, Belle SH, Fried MW


BACKGROUND: Patients with chronic hepatitis B virus (HBV) may experience spontaneous biochemical flares of liver disease activity. This study aimed to determine (i) the prevalence of prior and possible acute hepatitis E virus (HEV) infection among persons with chronic HBV and (ii) whether HEV infection is associated with liver disease flares among persons with chronic HBV. METHODS: Serum from a random sample of 600 adults in the Hepatitis B Research Network Cohort Study was tested for HEV RNA and anti-HEV IgM and IgG. Logistic regression models were used to estimate crude and adjusted odds ratios of anti-HEV prevalence for participant characteristics. RESULTS: Anti-HEV IgG and IgM seroprevalence was 28.5% and 1.7%, respectively. No participants had detectable HEV RNA. Of the 10 anti-HEV IgM+ participants, only 1 had elevated serum ALT at seroconversion. The odds of anti-HEV seropositivity (IgG+ or IgM+) were higher in older participants, males, Asians, less educated people, and those born outside the United States and Canada. CONCLUSIONS: Acute HEV infection is a rare cause of serum ALT flares among persons with chronic HBV. The high seroprevalence of anti-HEV IgG among the chronic HBV patients is strongly associated with various demographic factors in this largely Asian American cohort.

Category: Journal Article
PubMed ID: #31139669 DOI: 10.1093/ofid/ofz175
PubMed Central ID: #PMC6527087
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2018-12-23 Entry Last Modified: 2019-09-29