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U.S. Department of Health and Human Services

Scientific Publications by FDA Staff

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FEBS Lett 2019 Dec;593(24):3449-60

Interaction of adenovirus with antibodies, complement and coagulation factors.

Allen RJ, Byrnes AP


Adenovirus (AdV) is one of the most widely-used vectors for gene therapy and vaccine studies due to its excellent transduction efficiency, capacity for large transgenes and high levels of gene expression. When administered intravascularly, the fate of AdV vectors is heavily influenced by interactions with host plasma proteins. Some plasma proteins can neutralize AdV, but AdV can also specifically bind plasma proteins that protect against neutralization and preserve activity. This review summarizes the plasma proteins that interact with AdV, including antibodies, complement and vitamin K-dependent coagulation factors. We will also review the complex interactions of these plasma proteins with each other and with cellular proteins, as well as strategies for developing better AdV vectors that evade or manipulate plasma proteins.

Category: Journal Article, Review
PubMed ID: #31660588 DOI: 10.1002/1873-3468.13649
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2019-10-13 Entry Last Modified: 2020-01-06