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U.S. Department of Health and Human Services

Scientific Publications by FDA Staff

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Vaccines 2020 Jul 12;8(3):E382

Neutralizing antibodies targeting the conserved stem region of influenza hemagglutinin.

Nath Neerukonda S, Vassell R, Weiss CD


Influenza continues to be a public health threat despite the availability of annual vaccines. While vaccines are generally effective at inducing strain-specific immunity, they are sub-optimal or ineffective when drifted or novel pandemic strains arise due to sequence changes in the major surface glycoprotein hemagglutinin (HA). The discovery of a large number of antibodies targeting the highly conserved stem region of HAs that are capable of potently neutralizing a broad range of virus strains and subtypes suggests new ways to protect against influenza. The structural characterization of HA stem epitopes and broadly neutralizing antibody paratopes has enabled the design of novel proteins, mini-proteins, and peptides targeting the HA stem, thus providing a foundation for the design of new vaccines. In this narrative, we comprehensively review the current knowledge about stem-directed broadly neutralizing antibodies and the structural features contributing to virus neutralization.

Category: Journal Article, Review
PubMed ID: #32664628 DOI: 10.3390/vaccines8030382
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2020-06-07 Entry Last Modified: 2020-07-19