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Title:
Long depletion time of enrofloxacin in rainbow trout (Oncorhynchus mykiss).
Authors:
Lucchetti D, Fabrizi L, Guandalini E, Podesta E, Marvasi L, Zaghini A, Coni E
Drug:
Enrofloxacin
Fish species:
Trout, rainbow
Date:
2004
t1/2-hr:
168
est:
est
Sample:
muscle+skin
Ave Weight (gm):
250
Ave Water temp (°C):
13
Water:
Freshwater
Dosage:
10 mg/kg 5 d
Route:
PO
Comments:
Average Residue d0.5=0.56, d1=0.78, d2=0.68, d4=0.57, d7=0.18, d10=0.08, d20=LOD, d30=LOD, d40=LOD, d48=LOD, d60=LOD mg/kg. Cage study in a river. T 1/2 est from table.
Metabolites:
ciprofloxacin
Citation:
Antimicrobial Agents and Chemotherapy 48:3912-3917
Dep-time:
LOD at 265 deg day (approx 27 d at 10 deg C)
Link:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15388452
Genus Species:
Oncorhynchus mykiss
Drug Class:
Antibiotic-Quinolone
t1/2-detail:
7 day est at 12-13 deg
Wt gm-detail:
250 g
Water temp (°C)-detail:
13.25 C days 1-20, 12 C day 21+
Dosage-detail:
10 mg/kg 5d
Method:
HPLC
Authors-red:
Lucchetti D, Fabrizi L, Guandalini E, Podesta E, Marvasi L, Zaghini A, Coni E
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