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Title:
Tissue levels of oxolinic acid after oral and intravascular administration to freshwater and seawater rainbow trout.
Authors:
Ishida N
Drug:
Oxolinic acid
Fish species:
Trout, rainbow
Date:
1992
t1/2-hr:
24
est:
est
Sample:
blood, serum
Ave Weight (gm):
472
Ave Water temp (°C):
15
Water:
Saltwater
Dosage:
20 mg/kg sd
Route:
IV
Comments:
Fish acclimated in seawater 6 months. Serum levels were barely detectable by 144h vs 244 h of the freshwater group. Residues 0.5h=13.8, 3h=8.0, 24h=0.92, 72h=0.62, 144h=0.04ug/ml. No statistical difference from red sea bream held in seawater. Drug given under MS222. Glucuronide metabolites in bile of both salt and freshwater groups.
Citation:
Aquaculture 102:9-15
Link:
http://dx.doi.org/10.1016/0044-8486(92)90284-R
Genus Species:
Oncorhynchus mykiss
Drug Class:
Antibiotic-Quinolone
t1/2-detail:
< 24 h est
Wt gm-detail:
472 g
Water temp (°C)-detail:
15 C
Dosage-detail:
20 mg/kg sd
Method:
HPLC
Authors-red:
Ishida N
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