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Title:
Temperature-dependent absorption and elimination of flumequine in rainbow trout (Oncorhynchus mykiss Walbaum) in fresh water.
Authors:
Sohlberg S, Aulie A, Soli NE
Drug:
Flumequine
Fish species:
Trout, rainbow
Date:
1994
t1/2-hr:
137
Sample:
blood, plasma
Ave Weight (gm):
498
Ave Water temp (°C):
13
Water:
Freshwater
Dosage:
5 mg/kg sd
Route:
IVC
Comments:
Catheterized fish. Residues 2h=3.7, 4h=3.1, 8h=2.5, 12h=2.1, 24h=1.6, 36h=1.2, 48h=0.97, 73h= 0.9, 96h=0.8, 168h=0.7, 268h=0.5, 412h=0.6, 745h=0.2, 1070h=0.16, 1465h=0.11 (controls at 13C could have value of 0.13-0.22.) ug/ml. t1/2 alpha=2.9h, beta10.3, gamma137h.
Cl:
0.018 L/kg/h
Vd:
3.2 L/kg
Citation:
Aquaculture 119:1-10
Link:
http://dx.doi.org/10.1016/0044-8486(94)90439-1
Genus Species:
Oncorhynchus mykiss
Drug Class:
Antibiotic-Quinolone
t1/2-detail:
t1/2 alpha=2.9h, beta10.3, gamma137h.
Wt gm-detail:
499+/-133 g
Water temp (°C)-detail:
13+/-1 C
Dosage-detail:
5 mg/kg sd
Method:
HPLC
Authors-red:
Sohlberg S, Aulie A, Soli NE
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