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Title:
Pharmacokinetics and metabolism of sulphamonomethoxine in rainbow trout (Oncorhynchus mykiss) and yellowtail (Seriola quinqueradiata) following bolus intravascular administration.
Authors:
Uno K, Aoki T, Ueno R, Maeda I
Drug:
Sulfamonomethoxine
Fish species:
Amberjack, Japanese (yellowtail)
Date:
1997
t1/2-hr:
6
Sample:
blood, serum
Ave Weight (gm):
638
Ave Water temp (°C):
21
Water:
Saltwater
Dosage:
100 mg/kg sd
Route:
IV
Comments:
Protein binding for AcSMM= 6.3 +/- 2.3% Vd= 0.56 L/kg; Vc= 0.3 L/kg alpha=0.53h.
Protein binding:
5.8 +/- 1.7%
Cl:
0.067 L/kg/h
Vc:
0.3 L/kg
Vd:
0.56 L/kg
Metabolites:
N4-A-sulphamonomethoxine
Citation:
Aquaculture 153:1-8
Link:
http://dx.doi.org/10.1016/S0044-8486(97)00012-4
Genus Species:
Seriola quinqueradiata
Drug Class:
Antibiotic-Sulfa
t1/2-detail:
5.8 h
Wt gm-detail:
638 +/- 68 g
Water temp (°C)-detail:
21.3 +/- 0.2 C
Dosage-detail:
100 mg/kg sd
Method:
HPLC
Authors-red:
Uno K, Aoki T, Ueno R, Maeda I
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