Quick Links: Skip to main page content
Skip to Search
Skip to Topics Menu
Skip to Common Links
U.S. Food & Drug Administration
Follow FDA
En Español
Search FDA
Home
Food
Drugs
Medical Devices
Radiation-Emitting Products
Vaccines, Blood & Biologics
Animal & Veterinary
Cosmetics
Tobacco Products
PhishPharm - Detail
FDA Home
PhishPharm
Detail
-
Please note:
JavaScript must be enabled for this application to work properly.
Check your settings
if you are unsure if your JavaScript is enabled.
Title:
Comparative pharmacokinetics and bioavailability of oxytetracycline in rainbow trout and Chinook salmon.
Authors:
Abedini S, Namdari R, Law FCP
Drug:
Oxytetracycline
Fish species:
Trout, rainbow
Date:
1998
t1/2-hr:
94
Sample:
blood
Ave Weight (gm):
350
Ave Water temp (°C):
11
Water:
Freshwater
Dosage:
50 mg/kg sd
Route:
IVC
Comments:
Lower Vd than expected in both spp, maybe because implanted cannula; bioavailability of OTC after PO are 24.84% (salmon) and 30.30% (trout) which are higher than normal; Vd= 0.87l/kg. Conc went from 1000 ug/ml to approx 6 in first 200 h, then to 1 by 900h. AUC = 7781.2 ug h/ml.
Vd:
0.87 L/kg
Citation:
Aquaculture 162:23-32
Link:
http://dx.doi.org/10.1016/S0044-8486(97)00306-2
Genus Species:
Oncorhynchus mykiss
Drug Class:
Antibiotic-Tetracycline
t1/2-detail:
94.22 h
Wt gm-detail:
350 g
Water temp (°C)-detail:
11 C
Dosage-detail:
50 mg/kg sd
Method:
HPLC
Authors-red:
Abedini S, Namdari R, Law FCP
-
-