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Title:
Pharmacokinetics of eugenol in rainbow trout (Oncorhynchus mykiss).
Authors:
Guenette SA, Uhland FC, Helie P, Beaudry F, Vachon P
Drug:
Eugenol
Fish species:
Trout, rainbow
Date:
2007
t1/2-hr:
12
Sample:
blood
Ave Weight (gm):
64
Ave Water temp (°C):
4
Water:
Freshwater
Dosage:
75 mg/L for 15 min
Route:
BATH
Comments:
Liver, kidneys, heart, and gills were collected for histopathology, with no tissue anomalies revealed. Biphasic curve suggestive of enterohepatic circulation. Cmax = 10.53 ug/mL, AUCt = 16.55 ug h/mL, AUCinf = 17.04 ug h/mL. Used MS222 to take repeated blood samples. Estimated concentrations from graph: 1h=8.0 ug/ml, 2h=2.0, 5h=0.5, 10h=0.4, 20h=0.1 ug/ml.
Citation:
Aquaculture 266:262-265
Link:
http://dx.doi.org/10.1016/j.aquaculture.2007.02.046
Genus Species:
Oncorhynchus mykiss
Drug Class:
Anesthetic-Methoxyphenol
t1/2-detail:
12.14 h
Wt gm-detail:
63.7 +/- 14.4 g
Water temp (°C)-detail:
4 C
Dosage-detail:
75 mg/L for 15 min
Method:
LC, MS
Authors-red:
Guenette SA, Uhland FC, Helie P, Beaudry F, Vachon P
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