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Title:
Single dose pharmacokinetic study of flofenicol in tilapia (Oreochromis niloticus x O. aureus) held in freshwater at 22 C.
Authors:
Feng JB, Jia XP
Drug:
Florfenicol
Fish species:
Tilapia (hybrid)
Date:
2009
t1/2-hr:
11
Sample:
muscle
Ave Weight (gm):
98
Ave Water temp (°C):
22
Water:
Freshwater
Dosage:
10 mg/kg sd
Route:
PO
Comments:
Tmax reached at 12 h. Cmax concentration = 6.88 ug g. Drug elimination was rapid, became undetectable at 168 h. Tissue:plasma ratio: 2h=0.7, 4h=1.1, 6h=1.3, 8h= 1.1, 10h=1.1, 12h=1.5, 18h=1.6, 24h=1.3, 48h=1.4, 72h=0.9, 96h=0.4, 168h=0. Range = 0-1.56.
Citation:
Aquaculture 289: 129-133
Link:
http://dx.doi.org/10.1016/j.aquaculture.2008.12.023
Genus Species:
Oreochromis niloticus x O. aureus
Drug Class:
Antibiotic-Phenicol
t1/2-detail:
10.97 h
Wt gm-detail:
98g
Water temp (°C)-detail:
22 +/- 1 C
Dosage-detail:
10 mg/kg sd
Method:
HPLC
Authors-red:
Feng JB, Jia XP
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