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Title:
Distribution and elimination of oxolinic acid in rainbow trout (Oncorhynchus mykiss Walbaum) after single rapid intravascular injection.
Authors:
Hustvedt SO, Salte R
Drug:
Oxolinic acid
Fish species:
Trout, rainbow
Date:
1991
t1/2-hr:
53
Sample:
blood, serum
Ave Weight (gm):
575
Ave Water temp (°C):
9
Water:
Freshwater
Dosage:
10 mg/kg sd
Route:
IVC
Comments:
Mean serum conc ug/ml 15 min=15.0, 45 min=9.5, 90 min=5.7, 3h=3.4, 6h=3.0, 9h=2.4, 12h=2.5, 24h=1.8, 48h=1.5, 73h=1.2, 96h=1.0, 144h=0.7, 192h=nd. Cannulated fish. AUC=212 ug*h/ml. T1/2 alpha=0.5, beta=52.6h.
Cl:
0.05 L/kg/h
Vd:
2.9 L/kg
Citation:
Aquaculture 92:297-303
Link:
http://dx.doi.org/10.1016/0044-8486(91)90035-6
Genus Species:
Oncorhynchus mykiss
Drug Class:
Antibiotic-Quinolone
t1/2-detail:
alpha=0.5, beta=52.6h3, range-2.4-74.2 h beta
Wt gm-detail:
575+/-122 g
Water temp (°C)-detail:
8.5+/-0.5 C
Dosage-detail:
10 mg/kg sd
Method:
HPLC/RP, HPLC
Authors-red:
Hustvedt SO, Salte R
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