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Title:
Leaching, palatability and digestibility of oxytetracycline and oxolinic acid included in diets fed to seabass Dicentrarchus labrax L.
Authors:
Rigos G, Alexis M, Nengas I
Drug:
Oxolinic acid
Fish species:
Seabass, European
Date:
1999
Sample:
intestinal tract-feces
Ave Weight (gm):
350
Ave Water temp (°C):
16
Water:
Saltwater
Dosage:
30 mg/kg 3d
Route:
PO
Comments:
Drug well digested (94% +/- 4.3% at 24 C) but poorly digested at 16 C (64 +/-1.2%) (about 1/3 drug in feces). Oil coated feeds leached more antimicrobial if topcoated (55.5% loss at 16 and 32% at 24C), vs when mixed in feeds (5% at 16, 10% at 24C). In a repeat trial the OA still leached more at 16 C. Palatability not affected by top coating.
Citation:
Aquaculture Research 30:841-841-847
Link:
http://www.blackwell-synergy.com/doi/abs/10.1046/j.1365-2109.1999.00410.x?journalCode=are
Genus Species:
Dicentrarchus labrax
Drug Class:
Antibiotic-Quinolone
Wt gm-detail:
350 g
Water temp (°C)-detail:
16
Dosage-detail:
30 mg/kg 3d
Method:
HPLC
Authors-red:
Rigos G, Alexis M, Nengas I
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