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Title:
Dose-response relationships and pharmacokinetics of vitellogenin in rainbow trout after intravascular administration of 17[alpha]-ethynylestradiol.
Authors:
Schultz IR, Orner G, Merdink JL, Skillman A
Drug:
Vitellogenin
Fish species:
Trout, rainbow
Date:
2001
t1/2-hr:
49
Sample:
blood, plasma
Ave Weight (gm):
688
Ave Water temp (°C):
12
Water:
Freshwater
Dosage:
1.0 mg/kg of EE2*sd
Route:
IVC
Comments:
Cannulated fish. *Measured endogenous vitellogenin after induced by 17alpha-ethynylestradiol administration. Cmax 1521 ug/ml. T max=220h, AUC=402,800 ug/ml/h
Citation:
Aquatic Toxicology 51:305-318
Link:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11090892&query_hl=4
Genus Species:
Oncorhynchus mykiss
Drug Class:
Hormone-Estrogen
t1/2-detail:
49.5 +/- 19.8 h
Wt gm-detail:
688+/-107 g
Water temp (°C)-detail:
12 C
Dosage-detail:
1.0 mg/kg of EE2*sd
Method:
GC/MS
Authors-red:
Schultz IR, Orner G, Merdink JL, Skillman A
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