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Title:
Uptake, tissue distribution and excretion of domoic acid after oral exposure in coho salmon (Oncorhynchus kisutch).
Authors:
Lefebvre KA, Noren DP, Schultz IR, Bogard SM, Wilson J, Eberhart BTL
Drug:
Domoic acid
Fish species:
Salmon, coho
Date:
2007
Sample:
brain
Ave Weight (gm):
38
Ave Water temp (°C):
11
Water:
Freshwater
Dosage:
6.3 mg/kg sd
Route:
IC
Comments:
The onset of neuroexcitotoxic behavior following IC (intraccoelomic)injection was 30 +/-8 min. The mean level of domoic acid in brain resulting in this behavior was 170 +/- 28 ng/g tissue.
Citation:
Aquatic Toxicology 81:266-274
Link:
http://dx.doi.org/10.1016/j.aquatox.2006.12.009
Genus Species:
Oncorhynchus kisutch
Drug Class:
Organic-Phycotoxin
Wt gm-detail:
38 +/- 2g
Water temp (°C)-detail:
11 C
Dosage-detail:
6.3 mg/kg of demoic acid was administered via intracoelomic injection once
Method:
ELISA
Authors-red:
Lefebvre KA, Noren DP, Schultz IR, Bogard SM, Wilson J, Eberhart BTL
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