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Title:
Uptake, tissue distribution and excretion of domoic acid after oral exposure in coho salmon (Oncorhynchus kisutch).
Authors:
Lefebvre KA, Noren DP, Schultz IR, Bogard SM, Wilson J, Eberhart BTL
Drug:
Domoic acid
Fish species:
Salmon, coho
Date:
2007
Sample:
brain
Ave Weight (gm):
464
Ave Water temp (°C):
11
Water:
Freshwater
Dosage:
13 mg/kg sd
Route:
PO
Comments:
Domoic acid Cmax in brain was around 100 ug/ml. Toxin levels were low and varied little. The level of domoic acid in brain after ICO (intraccoelomic)exposure were higher than domoic level in brain of orally galvaged fish. No neurotoxic activity in PO treated fish.
Citation:
Aquatic Toxicology 81:266-274
Link:
http://dx.doi.org/10.1016/j.aquatox.2006.12.009
Genus Species:
Oncorhynchus kisutch
Drug Class:
Organic-Phycotoxin
Wt gm-detail:
48 +/- 7g
Water temp (°C)-detail:
11-13 C
Dosage-detail:
A dose of 10 mg/kg administered in 250 ul volume once
Method:
ELISA
Authors-red:
Lefebvre KA, Noren DP, Schultz IR, Bogard SM, Wilson J, Eberhart BTL
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