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Title:
Uptake, tissue distribution and excretion of domoic acid after oral exposure in coho salmon (Oncorhynchus kisutch)
Authors:
Lefebvre KA, Noren DP, Schultz IR, Bogard SM, Wilson J, Eberhart BTL
Drug:
Domoic acid
Fish species:
Salmon, coho
Date:
2007
Sample:
liver
Ave Weight (gm):
48
Ave Water temp (°C):
12
Water:
Freshwater
Dosage:
10 mg/Kg sd
Route:
PO
Comments:
Cmax around 1200 ng/ml, around 4h and 96h. Nd or nearly nd after 168h. Results estimated from graph. No neurotoxic activity in PO treated fish.
Citation:
Aquatic Toxicology 81:266-274
Link:
http://dx.doi.org/10.1016/j.aquatox.2006.12.009
Genus Species:
Oncorhynchus kisutch
Drug Class:
Organic-Phycotoxin
Wt gm-detail:
48 +/- 7g
Water temp (°C)-detail:
11-13 C
Dosage-detail:
A dose of 10 mg/kg administered in 250 ul volume once
Method:
ELISA
Authors-red:
Lefebvre KA, Noren DP, Schultz IR, Bogard SM, Wilson J, Eberhart BTL
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