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Title:
Uptake, tissue distribution and excretion of domoic acid after oral exposure in coho salmon (Oncorhynchus kisutch).
Authors:
Lefebvre KA, Noren DP, Schultz IR, Bogard SM, Wilson J, Eberhart BTL
Drug:
Domoic acid
Fish species:
Salmon, coho
Date:
2007
Sample:
whole body*
Ave Weight (gm):
46
Ave Water temp (°C):
11
Water:
Saltwater
Dosage:
0.7, 1.9, 3.4, 8.2, 18 and 21 mg/kg*
Route:
PO
Comments:
*Fish exposed to several doses for behavioral observation and dose-response curve. EC50 (toxin dose causing behavioral toxicity in 50% of population) was 5.6 mg/kg fish. IC (intra coelomic) injection of domoic acid in juvenile coho resulted in excitotoxic symptoms including spiral-, circle-, and upside-down swimming. Seawater adapted for 3 weeks before experiment. Euth with MS222.
Citation:
Aquatic Toxicology 81:266-274
Link:
http://dx.doi.org/10.1016/j.aquatox.2006.12.009
Genus Species:
Oncorhynchus kisutch
Drug Class:
Organic-Phycotoxin
Wt gm-detail:
46 +/- 9g
Water temp (°C)-detail:
11
Dosage-detail:
0.7+/-0.2, 1.9+/-0.2, 3.4+/-0.3, 8.2+/-2.0, 18+/-4.3 and 21+/-4.3 mg/kg
Method:
Behavioral observations
Authors-red:
Lefebvre KA, Noren DP, Schultz IR, Bogard SM, Wilson J, Eberhart BTL
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