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Title:
Pharmacokinetics, bioavailability, distribution, and metabolism of sulfadimethoxine in the rainbow trout (Oncorhynchus mykiss).
Authors:
Kleinow KM, Beilfuss WL, Jarboe HH, Droy BF, Lech JJ
Drug:
Sulfadimethoxine
Fish species:
Trout, rainbow
Date:
1992
t1/2-hr:
16
Sample:
blood, plasma
Ave Weight (gm):
637
Ave Water temp (°C):
13
Water:
Freshwater
Dosage:
42 mg/kg sd
Route:
IVC
Comments:
Bioavailability=34 +/- 8.5%, t1/2 alpha=0.63 +/-0.33 h. Sulfadimethoxine-not labeled.
Protein binding:
15.8 +/- 5.1%
Cl:
0.021 L/kg/h
Vd:
0.42 L/kg
Metabolites:
N4-A-SDM
Citation:
Canadian J. Fisheries and Aquatic Sciences 49:1070-1077
Link:
http://www.nrcresearchpress.com/doi/abs/10.1139/f92-118
Genus Species:
Oncorhynchus mykiss
Drug Class:
Antibiotic-Sulfa
t1/2-detail:
15.9 +/-5.4 h
Wt gm-detail:
180-650 or 650-1094g
Water temp (°C)-detail:
13 +/-1 C
Dosage-detail:
42 mg/kg sd
Method:
HPLC-Rad
Authors-red:
Kleinow KM, Beilfuss WL, Jarboe HH, Droy BF, Lech JJ
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