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Title:
Pharmacokinetics of morphine in fish: Winter flounder (Pseudopleuronectes americanus) and seawater-acclimated rainbow trout (Oncorhyncus mykiss).
Authors:
Newby NC, Mendonca PC, Gamperl K, Stevens ED
Drug:
Morphine
Fish species:
Trout, rainbow
Date:
2006
t1/2-hr:
14
Sample:
blood, plasma
Ave Weight (gm):
1003
Ave Water temp (°C):
10
Water:
Saltwater
Dosage:
39 mg/kg sd
Route:
IP
Comments:
A = 82.5 +/- 8.5 mg/L, ± = 0.500 +/- 0.032 per hour, B = 4.08 +/- 1.23 mg/L, ² = 0.0527 +/- 0.0051 per hour, T1/2dist = 1.43 +/- 0.09 h, AUCexpo = 245 +/- 36 mg h/L, AUCarea = 290 +/- 37 mg h/L, AUMCexpo = 1800 +/- 378 mg h2/L, AUMCarea = 2055 +/- 345 mg h2/L, MRTarea = 7.0 +/- 0.6 h. (Morphine Sulfate).
Cl:
0.153 L/kg/h
Citation:
Comparative Biochemistry and Physiology 143C:275-283
Link:
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16631414&ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Genus Species:
Oncorhynchus mykiss
Drug Class:
Analgesic-Morphine
t1/2-detail:
13.9 +/- 1.1
Wt gm-detail:
1003 +/- 64 g
Water temp (°C)-detail:
10 C
Dosage-detail:
39.3 +/- 0.1 mg/kg
Method:
ELISA
Authors-red:
Newby NC, Mendonca PC, Gamperl K, Stevens ED
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