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Title:
Accumulation and clearance of orally administered erythromycin and its derivative, azithromycin, in juvenile fall chinook salmon Oncorhynchus tshawytscha.
Authors:
Fairgrieve WT, Masada CL, McAuley WC, Peterson ME, Myers MS, Strom MS.
Drug:
Erythromycin
Fish species:
Salmon, chinook
Date:
2005
Sample:
whole body
Ave Weight (gm):
0
Ave Water temp (°C):
10
Water:
Freshwater
Dosage:
100 mg/kg/d 28 d
Route:
PO
Comments:
Average tissue concentrations: 42d= 0.2, 91d= 2.5 and 141d = 10.4 ug/g. Drug was eliminated within 21 days post-exposure. No significant effect of mulitple exposure on whole body antibiotic concentration. No histopathologically significant lesion in trunk kidney and other organ tissues. Half life could not be estimated because tissue concentrations were below tissue limit by 2nd post-treatment sampling. Tissue concentration varied between 0.2 ug/g in fry to 10.4 ug/g in smolts. The smallest fish (0.5-1.3g) received one treatment, medium sized (3.0-5.6g) received two, and the largest fish (11.0-15.3g) received three treatments before sampling. Although it appears that accumulation was higher in the larger fish, the data was not statistically significant.
Citation:
Diseases of Aquatic Organisms 64:99-106
Dep-time:
within 21 d
Link:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15918472&query_hl=9
Genus Species:
Oncorhynchus tshawytscha
Drug Class:
Antibiotic-Macrolide
t1/2-detail:
< 21 d
Wt gm-detail:
11.1-13.0 g
Water temp (°C)-detail:
10 C
Dosage-detail:
100 mg/kg/d 28 d
Method:
Micro
Authors-red:
Fairgrieve WT, Masada CL, McAuley WC, Peterson ME, Myers MS, Strom MS.
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