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PhishPharm - Detail
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Title:
Relative roles of metabolism and renal excretory mechanisms in xenobiotic elimination by fish.
Authors:
Pritchard JB, Bend JR
Drug:
BAP-(Benzo-a-pyrene)
Fish species:
Flounder, southern
Date:
1991
Sample:
blood, plasma
Ave Weight (gm):
1750
Ave Water temp (°C):
23
Water:
Saltwater
Dosage:
2.5 umol/kg
Route:
IV/IM
Comments:
Half the dose administerd IV, the remainder was given IM. BaP (3H). Given with polyethyleneglycol (14C) as marker for GFR. 1-5 umole/ml ave for 0-6 hr. 7.1 nmole/ml < 3 hr, 6.4 >3 hr.
Cl:
0.2 ml/h < 3 h vs 3.8 ml/h > 3 h
Citation:
Environmental Health Perspectives 90:85-92
Link:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2050085
Genus Species:
Paralichthys lethostigma
Drug Class:
Organic-Hydrocarbon
Wt gm-detail:
500-3000 g
Water temp (°C)-detail:
22-24 C
Dosage-detail:
2.5 umol/kg
Method:
HPLC
Authors-red:
Pritchard JB, Bend JR
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